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New treatment option for Stroke
Official title tACS to Enhance Language Abilities
ClinicalTrials.gov ID: NCT06092814
What this study is testing
- What it's testing
- The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85. Healthy volunteers may be eligible.
You may be able to join if
- for Persons with Aphasia:
- Presence of aphasia
- Suffered a single, left hemisphere stroke
- Stroke ≥6 months old (chronic) at the time of enrollment for Healthy Controls:
- Right-handedness
You likely can't join if
- for Persons with Aphasia:
- Inability to understand the nature of the study
- Marked naming impairment
- Impaired non-verbal, conceptual processing
- History of significant medical or neurological disorder (other than stroke)
- History of significant or poorly controlled psychiatric disorders
See the full eligibility criteria
- for Persons with Aphasia:
- Presence of aphasia
- Suffered a single, left hemisphere stroke
- Stroke ≥6 months old (chronic) at the time of enrollment for Healthy Controls:
- Right-handedness
- Must be able to understand the nature of the study, and give informed consent
- for Persons with Aphasia:
- Inability to understand the nature of the study
- Marked naming impairment
- Impaired non-verbal, conceptual processing
- History of significant medical or neurological disorder (other than stroke)
- History of significant or poorly controlled psychiatric disorders
- Current abuse of alcohol or drugs, prescription or otherwise
- Nursing a child, pregnancy, or intent to become pregnant during the study
- Clinically significant hearing loss
- Contraindications to tACS
- Contraindications to MRI Exclusion Criteria for Healthy Controls
- Diagnosis of a neurodegenerative disease or clinically significant cognitive complaint
- Any unrelated neurologic or physical condition that impairs communication ability
- History of unrelated neurological conditions including but not limited to traumatic brain injury, stroke, or small vessel disease that has resulted in a neurologic deficit
- Any additional neurological condition that would likely reduce the safety of study participation, including central nervous system (CNS) vasculitis, intracranial tumor, intracranial aneurysm, multiple sclerosis or...
- A medically unstable cardiopulmonary or metabolic disorder
- Terminal illness associated with survival \<12 months
- Major active psychiatric illness that may interfere with required study procedures or treatments as determined by the enrolling physician
- Current abuse of alcohol or drugs, prescription or otherwise
- Contraindications to tACS
- Contraindications to MRI
The study team makes the final eligibility decision.
Where it's taking place
- Philadelphia, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.