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New treatment option for Depression, Unipolar
Official title Effects of CBT and BLT in Youth With Unipolar Depression and Evening Chronotype
ClinicalTrials.gov ID: NCT06092411
What this study is testing
- What it's testing
- The goal of this prospective randomised controlled trial is to examine the effects of cognitive behavioural therapy and bright light therapy in youths with unipolar depression and evening chronotype. The main questions it aims to answer are: 1.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 to 20
You may be able to join if
- Chinese aged 12-20 years old.
- Written informed consent of participation into the study is given by the participant and his/her parent or guardian (for those aged under 18).
- Being able to comply with the study protocol.
- Having a DSM-5 diagnosis of depressive disorders.
- Having a score of ≥ 40 on Children's Depression Rating Scale (CDRS-R).
You likely can't join if
- A current diagnosis of substance abuse or dependence; a current or past history of manic or hypomanic episode, schizophrenia spectrum disorders...
- Initiation of and change of medication that may interfere with circadian rhythm within past 3 months (e.g., lithium, exogenous melatonin...
- In the opinion of the research clinician, having a clinically significant suicidality (presence of suicidal ideation with a plan or an attempt).
- Having been enrolled in any other clinical trial investigational products within one month at the entry of the study.
- Initiation of or change in antidepressant medication within past 3 months.
- Having been or is currently receiving any structured psychotherapy.
See the full eligibility criteria
- Chinese aged 12-20 years old.
- Written informed consent of participation into the study is given by the participant and his/her parent or guardian (for those aged under 18).
- Being able to comply with the study protocol.
- Having a DSM-5 diagnosis of depressive disorders.
- Having a score of ≥ 40 on Children's Depression Rating Scale (CDRS-R).
- Having a score of ≤ 41 on Horne-Östberg Morning-Eveningness Questionnaire (MEQ; classified as evening chronotype).
- Having a sleep onset time of 11:15pm or later for 12 year olds, 11:30pm or later for 13-14 year olds, and 12:00pm or later for 15-20 years at least 3 nights per week in the past 3 months.
- A current diagnosis of substance abuse or dependence; a current or past history of manic or hypomanic episode, schizophrenia spectrum disorders, neurodevelopmental disorders, organic mental disorders, or intellectual...
- Initiation of and change of medication that may interfere with circadian rhythm within past 3 months (e.g., lithium, exogenous melatonin, melatonergic antidepressants).
- In the opinion of the research clinician, having a clinically significant suicidality (presence of suicidal ideation with a plan or an attempt).
- Having been enrolled in any other clinical trial investigational products within one month at the entry of the study.
- Initiation of or change in antidepressant medication within past 3 months.
- Having been or is currently receiving any structured psychotherapy.
- With hearing or speech deficit.
- Night shift worker.
- Trans-meridian flight in the past 1 month and during intervention.
- Presence of an eye disease (e.g., retinal blindness, severe cataract, glaucoma).
The study team makes the final eligibility decision.
Where it's taking place
- Hong Kong, Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years to 20 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hong Kong, Hong Kong. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.