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Tests treatment safety and results for Suicide
Official title Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
ClinicalTrials.gov ID: NCT06085937
What this study is testing
What is Ketamine?
Ketamine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for suicide.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
- Require inpatient stabilization for SI or actions based on clinical observation and interview
- Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
- Have a Glasgow Coma Score (GCS) of 15
- Age 18-65
You likely can't join if
- Current or past history of psychosis
- Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
- History of ketamine use disorder
- History of liver transplant
- Pregnancy or breastfeeding
- Imprisonment or inability to consent
See the full eligibility criteria
- Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
- Require inpatient stabilization for SI or actions based on clinical observation and interview
- Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
- Have a Glasgow Coma Score (GCS) of 15
- Age 18-65
- Current or past history of psychosis
- Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
- History of ketamine use disorder
- History of liver transplant
- Pregnancy or breastfeeding
- Imprisonment or inability to consent
- Positive urine drug screen or serum alcohol level
- Hypertension (SBP \> 160 or DBP \> 100 before administration of ketamine)
- Hypotension (SBP \< 90)
- Presence of acute medical condition requiring admission to medical service
- Allergy, intolerance, or previous adverse reaction to ketamine
- Patient has 8+ lifetime ketamine exposures
- The treating physician determines that the patient is not a good candidate for the study (e.g. medical condition/procedure, medication that would contradindicate ketamine treatment)
The study team makes the final eligibility decision.
Where it's taking place
- Kansas City, Kansas, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kansas City, Kansas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.