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New treatment option for Alzheimer Disease, Early Onset
Official title Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
ClinicalTrials.gov ID: NCT06080659
What this study is testing
- What it's testing
- The aim of the NODAL clinical trial is to demonstrate the feasibility of new, low-cost, non-invasive biomarkers of neurodegenerative pathologies as early Alzheimer and Parkinson, based on the estimation of the multimodal connectome.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80. Healthy volunteers may be eligible.
You may be able to join if
- For all participants:
- French mother tongue
- right-handed
- with a level of education equal to or higher than the Certificat d'Études Primaires (Primary School Certificate)
- Free of any medical or psychiatric condition likely to interfere with cognition (excluding diagnosis for patients)
You likely can't join if
- All participants (healthy volunteers and patients)
- Contraindications to MRI :
- Abdominal circumference + upper limbs sticking to the body \> 200 cm;
- Implantable pacemaker or defibrillator;
- Neurosurgical clips;
- Cochlear implants ;
See the full eligibility criteria
- For all participants:
- French mother tongue
- right-handed
- with a level of education equal to or higher than the Certificat d'Études Primaires (Primary School Certificate)
- Free of any medical or psychiatric condition likely to interfere with cognition (excluding diagnosis for patients)
- Affiliated with a social security scheme
- Having received oral and written information about the protocol and having signed a consent form to participate in this research. DCS+ group: \- Meeting the diagnostic criteria for "subjective cognitive decline-plus"...
- All participants (healthy volunteers and patients)
- Contraindications to MRI :
- Abdominal circumference + upper limbs sticking to the body \> 200 cm;
- Implantable pacemaker or defibrillator;
- Neurosurgical clips;
- Cochlear implants ;
- Neural or peripheral stimulator;
- Intra-orbital or encephalic metallic foreign bodies;
- Endoprostheses fitted less than 4 weeks ago and osteosynthesis devices fitted less than 6 weeks ago;
- Claustrophobia.
- Pregnant or breast-feeding women;
- Adults under legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty. Patients only
- Score \>2 on the modified Hachinski scale (Hachinski et al., 2012)
- Dementia according to McKhann criteria (McKhann et al., 2011)
- Sensory deficit interfering with experimental tests Healthy volunteers only \- Cognitive impairment (MoCA score \< 26)
The study team makes the final eligibility decision.
Where it's taking place
- Rennes, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Rennes, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.