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New treatment option for Langerhans Cell Histiocytosis of Bone
Official title Oral Prednisone in Treating LCH of Bone in Childhood and Adolescence
ClinicalTrials.gov ID: NCT06078969
What this study is testing
What is Prednisone?
Prednisone is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for langerhans cell histiocytosis of bone.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Langerhans cell histiocytosis (LCH) of bone is a benign-tumor-like osteolytic lesion in childhood and adolescence, which is characterized by the aberrant activation of antigen presenting cells. Rather than the multi-system involvements of LCH, no standard or widely-accepted therapeutic regimens were established for LCH of bone.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 2 to 17
You may be able to join if
- Pathological diagnosis of Langerhans cell histiocytosis (LCH) of bone;
- Single-system involvement (skeletal system);
- No need of surgical intervention;
- Must be able to swallow tablets;
- Signing informed consent form.
You likely can't join if
- Multi-system involvements (≥2 systems, including bone, liver, spleen, hematologic system, central nerve system);
- Need of surgical intervention (e.g. pathological fracture and/or spinal cord compression)
- Glucocorticoid allergy;
- Immunodeficiency;
- Severe infection;
- Insulin dependent/independent Diabetes;
See the full eligibility criteria
- Pathological diagnosis of Langerhans cell histiocytosis (LCH) of bone;
- Single-system involvement (skeletal system);
- No need of surgical intervention;
- Must be able to swallow tablets;
- Signing informed consent form.
- Multi-system involvements (≥2 systems, including bone, liver, spleen, hematologic system, central nerve system);
- Need of surgical intervention (e.g. pathological fracture and/or spinal cord compression)
- Glucocorticoid allergy;
- Immunodeficiency;
- Severe infection;
- Insulin dependent/independent Diabetes;
- Having taken glucocorticoid in the past two weeks;
- Not capable of swallowing tablets;
- Without signed informed consent inform.
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 2 years to 17 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.