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New treatment option for Early Syphilis, Latent, Serological Relapse After Treatment
Official title Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline
ClinicalTrials.gov ID: NCT06069141
What this study is testing
What is Benzathine Penicillin G?
Benzathine Penicillin G is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for early syphilis, latent, serological relapse after treatment.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This randomized controlled superiority study will be conducted during 2023-2025. The eligible participants are adult people living with HIV (PLWH) who are newly diagnosed with early syphilis.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- People living with HIV (PLWH) aged ≥18 years with early syphilis
- Confirmed by a positive RPR titer with a reactive TPPA assay
You likely can't join if
- PWH with RPR titers of \<4
- Exposure to antibiotics with activity against T. pallidum within the preceding 4 weeks (penicillin, 3rd cephalosporin, doxycycline, macrolides)
- A known or suspected infection requiring additional treatment with an antimicrobial active against T. pallidum (penicillin, 3rd cephalosporin...
- Testing positive for C. trachomatis and M. genitalium, for which doxycycline or macrolide was administered
- A history of intolerance to penicillin or doxycycline
- PLWH have already participated in this study
See the full eligibility criteria
- People living with HIV (PLWH) aged ≥18 years with early syphilis
- Confirmed by a positive RPR titer with a reactive TPPA assay
- PWH with RPR titers of \<4
- Exposure to antibiotics with activity against T. pallidum within the preceding 4 weeks (penicillin, 3rd cephalosporin, doxycycline, macrolides)
- A known or suspected infection requiring additional treatment with an antimicrobial active against T. pallidum (penicillin, 3rd cephalosporin, doxycycline, macrolides)
- Testing positive for C. trachomatis and M. genitalium, for which doxycycline or macrolide was administered
- A history of intolerance to penicillin or doxycycline
- PLWH have already participated in this study
- Pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Hsinchu, Taiwan, Taiwan
- Taipei, Taiwan, Taiwan
- Taoyuan, Taiwan, Taiwan
- Kaohsiung City, Taiwan
- Tainan, Taiwan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hsinchu, Taiwan, Taiwan; Taipei, Taiwan, Taiwan; Taoyuan, Taiwan, Taiwan; Kaohsiung City, Taiwan; Tainan, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.