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New treatment option for VAP - Ventilator Associated Pneumonia
Official title Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
ClinicalTrials.gov ID: NCT06045429
What this study is testing
What is Oroxid®?
Oroxid® is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for vap - ventilator associated pneumonia.
Also referred to as 3% hydrogen peroxide mouthwash.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- HyPerMICROBE is a single-centre, controlled, randomised, prospective, superiority clinical trial to compare the efficacy of daily oral care with 3% hydrogen peroxide (Oroxid®) versus standard of care (0.2% chlorhexidine digluconate) on the cumulative incidence of lower respiratory tract microbial colonisation in mechanically ventilated adult critically ill patients.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years
- In-patient of ICU and expected to stay \> 5 days
- Mechanical ventilation or imminent need of it; predicted length of mechanical ventilation (MV) ≥ 72h
- Clinical Pulmonary Infection score (CPIS) less than 6 at the baseline
- No history and symptoms of aspiration at the baseline
You likely can't join if
- ATB therapy of respiratory infection on admission
- Suspected pulmonary infection on admission and in the first 48h of mechanical ventilation
- Pregnancy
- Oral ulcers or injuries
- Patient with a history of hydrogen peroxide allergy
The study team makes the final eligibility decision.
Where it's taking place
- Prague, Czechia
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Prague, Czechia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.