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Official title Effect of Vagal Nerve Stimulation on Gastric Motor Functions
ClinicalTrials.gov ID: NCT06038929
What this study is testing
- What it's testing
- The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to a caloric meal In patients who have previously undergone activation of left cervical VNS for the treatment of medication-resistant depression. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying compared to a bank of healthy control data.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- General criteria
- Participant must be at least 18 years old.
- Participant must have the capacity to provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.
- Participant is diagnosed with drug Resistant Epilepsy and previously underwent implantation of VNS. and/or
- Participant is diagnosed with treatment-refractory depression and previously underwent implantation of VNS.
You likely can't join if
- GENERAL criteria
- Participant has a prior implantable stimulation device other than a VNS device for the clinical indication of refractory focal Epilepsy or for...
- Participant currently uses or during the study is expected to use short-wave diathermy, microwave, diathermy, or therapeutic ultrasound diathermy.
- Participant has a diagnosis of Substance Use Disorder as defined by DSM-5 without sustained remission of 12 months or longer.
- Patient participated in another drug or device trial within the preceding 30 days (other than REVEAL studies).
- Participant has been hospitalized for a psychiatric condition within the preceding 6 months or has had a history of psychosis within the preceding...
See the full eligibility criteria
Who can join
- General criteria
- Participant must be at least 18 years old.
- Participant must have the capacity to provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.
- Participant is diagnosed with drug Resistant Epilepsy and previously underwent implantation of VNS. and/or
- Participant is diagnosed with treatment-refractory depression and previously underwent implantation of VNS.
- Participant has completed the REVEAL CSP and has been stabilized by their care team on a stable VNS setting
- Apart from epilepsy or depression, participant should be medically and neurologically stable.
- Participant is able to complete regular office visits and telephone appointments including the imaging session in accordance with the study protocol requirements.
- Participant that is of childbearing potential must be adequately protected from conception or willing to use an acceptable method of birth control over the entire study duration (acceptable birth control includes...
- Participant must be enrolled in an active health insurance plan that will cover the costs associated with standard health care services and injuries.
What rules you out
- GENERAL criteria
- Participant has a prior implantable stimulation device other than a VNS device for the clinical indication of refractory focal Epilepsy or for depression.
- Participant currently uses or during the study is expected to use short-wave diathermy, microwave, diathermy, or therapeutic ultrasound diathermy.
- Participant has a diagnosis of Substance Use Disorder as defined by DSM-5 without sustained remission of 12 months or longer.
- Patient participated in another drug or device trial within the preceding 30 days (other than REVEAL studies).
- Participant has been hospitalized for a psychiatric condition within the preceding 6 months or has had a history of psychosis within the preceding two years (excluding post-ictal psychosis).
- Participant has experienced unprovoked status epilepticus in the preceding year.
- Participant is not able or willing to use their dominant arm, or either upper arm circumference is greater than 50 cm.
- Any other clinical reasons deemed by the investigators of the study for which the participant would not be an appropriate candidate for the study, such as peripheral vascular disease, Raynaud's phenomenon, orthostatic...
- Participant with vocal cord paralysis
- Participant cannot speak and read English.
- Participant is pregnant.
- Prohibited Therapy During Study Period: We will exclude patients on immunosuppressants, beta blockers, anticholinergics, and clonidine. Consultation with primary providers and amending some of these therapies may be...
- A body weight of over 350 pounds or 159 kilograms due to equipment limitations used in the measurements of gastric accommodation and emptying.
- An inability to eat eggs whether due to an allergy, intolerance, or strong dislike. The gastric emptying test meal contains eggs that are labeled with radioisotope. Other food substitutions for the toast, butter and...
- Any other factor that may impact participant safety or compliance as per PI. Since participants with pVNS will be recruited from the CSP study at U Minnesota, it is important to specify the inclusion and exclusion...
- Participant must be at least 18 years old.
- Participant must have the capacity to provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.
- Participant must be enrolled in an active health insurance plan that will cover the costs associated with standard health care services and injuries.
- Participant must have been previously implanted with a VNS device for the clinical indication of Major Depressive Disorder (MDD).
- Participant must have a score on the baseline administration of the Montgomery-Åsberg Depression Rating Scale (MADRS) of ≥ 22.
- Participant must be able and willing to complete the evaluations and procedures described in the study protocol.
- Participant must be able and willing to follow the stipulations regarding concomitant medications and excluded medications described in section 5.3 of the study protocol.
- Participant that is of childbearing potential must be adequately protected from conception or willing to use an acceptable method of birth control over the entire study duration (acceptable birth control includes...
- Participant has a prior implantable stimulation device, other than a VNS device for the clinical indication of Major Depressive Disorder (MDD).
- Participant currently uses or is expected during the study to use short-wave diathermy, microwave, diathermy, or therapeutic ultrasound diathermy.
- Participant is judged by the investigator to be acutely suicidal (e.g. has made specific plans or preparations to commit suicide or as indicated by the Sheehan Suicidality Tracking Scale) within the last 30 days prior...
- Participant has made a suicide attempt within the previous 6 months from study enrollment.
- Participant has a history of one or more schizophrenia-spectrum or other psychotic disorders including schizophrenia, schizoaffective disorder, delusional disorder, or a current or lifetime major depressive episode that...
- Participant has a history of significant borderline or severe personality disorder as determined by clinical judgment.
- Participant has an active primary diagnosis of obsessive-compulsive, eating, or post-traumatic stress disorder based on the MINI criteria.
- Participant has a diagnosis of Substance Use Disorder as defined by DSM-5 without sustained remission of 12 months or longer.
- Participant has a presence of any type of dementia, major neurocognitive disorder, or cognitive or psychiatric deficit as determined by clinical judgment.
- Participant has a history of rapid cycling bipolar disorder I or II.
- Participant currently receives treatment with another investigational device or investigational drug other than the REVEAL study (or a REVEAL ancillary project or sub-study) or has participated in another drug or device...
- Participant is not able or willing to use their dominant arm, or either upper arm circumference is greater than 50 cm.
- Participant does not speak English.
- Participant is pregnant.
- Any other clinical reasons deemed by the investigators of the study for which the participant would not be an appropriate candidate for the study, such as peripheral vascular disease, Raynaud's phenomenon, orthostatic...
- Participant must be at least 18 years old.
- Participant must have the capacity to provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.
- Participant must be enrolled in an active health insurance plan that will cover the costs associated with standard health care services and injuries.
- Participant must have been previously implanted with a VNS device for the clinical indication of drug resistant epilepsy.
- Participant has not had demonstrable benefit from the implanted VNS device in terms of epilepsy (seizure frequency or seizure severity) or related epilepsy comorbidities (mood, cognition, quality of life), with no...
- Apart from epilepsy, the participant should be medically and neurologically stable.
- Participant must be able and willing to complete the evaluations and procedures described in the study protocol.
- Participant must be able and willing to follow the stipulations regarding concomitant medications and excluded medications described in section 5.3 of the study protocol.
- Participant that is of childbearing potential must be adequately protected from conception or willing to use an acceptable method of birth control over the entire study duration (acceptable birth control includes...
- Participant has demonstrable benefit from implanted VNS device in terms of epilepsy (seizure frequency or seizure severity) or epilepsy comorbidity (mood, cognition, or quality of life), with seizure freedom or clinical...
- Participant has a prior implantable stimulation device, other than a VNS device for the clinical indication of refractory focal Epilepsy.
- Participant currently uses or is expected during the study to use short-wave diathermy, microwave, diathermy, or therapeutic ultrasound diathermy.
- Participant has been hospitalized for a psychiatric condition within the preceding 6 months or has had a history of psychosis within the preceding two years (excluding postictal psychosis).
- Participant has experienced unprovoked status epilepticus in the preceding year.
- Participant has a diagnosis of Substance Use Disorder as defined by DSM-5 without sustained remission of 12 months or longer.
- Participant currently receives treatment with another investigational device or investigational drug other than the REVEAL study (or a REVEAL ancillary project or sub-study) or has participated in another drug or device...
- Participant is not able or willing to use their dominant arm, or either upper arm circumference is greater than 50 cm.
- Participant does not speak English.
- Participant is pregnant.
- Any other clinical reasons deemed by the investigators of the study for which the participant would not be an appropriate candidate for the study, such as peripheral vascular disease, Raynaud's phenomenon, orthostatic...
The study team makes the final eligibility decision.
Where it's taking place
- Minneapolis, Minnesota, United States
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Minneapolis, Minnesota, United States; Rochester, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.