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Compares treatment options for Acute Kidney Injury
Official title IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients
ClinicalTrials.gov ID: NCT06032884
What this study is testing
- What it's testing
- Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU. Randomized controlled trials (RCTs) comparing IHD and CRRT for AKI have not shown an indisputable benefit of one technique over the other.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults (\> or= 18 years old) in ICU
- Receiving (or who have received) invasive mechanical ventilation and/or catecholamine infusion
- Availability of both equipment IHD and CRRT (in the investigational center at the time of inclusion)
- One of the 2 following situations 4.a: Either at least one of the 3 following complications of AKI\ (whatever the KDIGO stage): persistent severe...
- Affiliation of social security system
You likely can't join if
- Moribund state (patient likely to die within 24h)
- Previous inclusion in the study
- Subject deprived of freedom, or under a legal protective measure (example: patients under guardianship or curatorship)
- Subject receiving state medical aid
- Pregnancy or breastfeeding woman
- Patient included in another research trial on AKI
See the full eligibility criteria
- Adults (\> or= 18 years old) in ICU
- Receiving (or who have received) invasive mechanical ventilation and/or catecholamine infusion
- Availability of both equipment IHD and CRRT (in the investigational center at the time of inclusion)
- One of the 2 following situations 4.a: Either at least one of the 3 following complications of AKI\ (whatever the KDIGO stage): persistent severe hyperkalaemia despite medical treatment, persistent severe metabolic...
- Affiliation of social security system
- Written consent obtained from the patients (from a support person, family member or a close relative if the patient is not able to expressing and sign consent) or inclusion without initial consent in case of emergency...
- Moribund state (patient likely to die within 24h)
- Previous inclusion in the study
- Subject deprived of freedom, or under a legal protective measure (example: patients under guardianship or curatorship)
- Subject receiving state medical aid
- Pregnancy or breastfeeding woman
- Patient included in another research trial on AKI
- Advanced chronic kidney disease (CKD) defined by an estimated GFR\<20 mL/min/1.73 m2
- Presence of a drug overdose or of a dialyzable toxin that necessitates RRT (because IHD may be preferable in these conditions).
- Presence or clinical suspicion of renal obstruction, rapidly progressive glomerulonephritis, vasculitis, thrombotic microangiopathy or acute interstitial nephritis
- Brain injured patients or other causes of increased intracranial pressure
- Fulminant hepatic failure
The study team makes the final eligibility decision.
Where it's taking place
- Bobigny, France
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bobigny, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.