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Official title Cerebrovascular Health and Resilience in Midlife
ClinicalTrials.gov ID: NCT06029348
What this study is testing
- What it's testing
- This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 59. Healthy volunteers may be eligible.
You may be able to join if
- Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania)
- Able to read and speak English
You likely can't join if
- Uncontrolled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100 mmHg)
- Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications
- Current use of glucocorticoids (e.g., oral prednisone) or ephedrine
- Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances...
- Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury)
- Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia)
See the full eligibility criteria
- Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania)
- Able to read and speak English
- Uncontrolled hypertension (systolic blood pressure \>160 or diastolic blood pressure \>100 mmHg)
- Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications
- Current use of glucocorticoids (e.g., oral prednisone) or ephedrine
- Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma...
- Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury)
- Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia)
- Current pregnancy or childbirth within the past 6 months
- Suspected mild cognitive impairment or dementia
- Self reported sleep apnea
- Self-reported history of myocardial infarction, stroke, or revascularization procedures, as well as treatment for cardiac arrhythmias
- Self-reported lack of comfort to undergo MRI testing
- Presence of implants or objects that are unsafe for MRI (e.g., tattooed eyeliner), as well as any other contraindications that would prevent MRI testing
- Self-reported lack of comfort to undergo the laboratory math task
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 59 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.