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Compares treatment options for Anesthesia
Official title Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine
ClinicalTrials.gov ID: NCT06029049
What this study is testing
What is Modified Time Principle Induction (MTPI) with rocuronium?
Modified Time Principle Induction (MTPI) with rocuronium is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for anesthesia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, and movement of limbs and coughing during tracheal intubation in order to assess intubation conditions, to compare efficiency and success rate of tracheal intubation between two induction agents and to determine the rate of patient awareness during induction and post-operative recall of paralysis.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- BMI \> 30kg/m2 or Mallampati class III or IV.
- Requiring general anesthesia and endotracheal intubation
You likely can't join if
- Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma.
- The American Society of Anesthesiologists (ASA) physical status classification \> III.
- Patients requiring awake intubation.
- Pregnant women.
- Untreated ischemic heart disease.
- Patients requiring an induction dose of propofol \< 1 mg/kg.
See the full eligibility criteria
- BMI \> 30kg/m2 or Mallampati class III or IV.
- Requiring general anesthesia and endotracheal intubation
- Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma.
- The American Society of Anesthesiologists (ASA) physical status classification \> III.
- Patients requiring awake intubation.
- Pregnant women.
- Untreated ischemic heart disease.
- Patients requiring an induction dose of propofol \< 1 mg/kg.
- Allergy to propofol, rocuronium, succinylcholine, or sugammadex.
- Patients with renal failure and unknown potassium (K+) level, or patients with K+ level \> 5.0
- Personal history of malignant hyperthermia (MH), or family history of MH
- Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries
The study team makes the final eligibility decision.
Where it's taking place
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Houston, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.