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New treatment option for Migraine
Official title Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
ClinicalTrials.gov ID: NCT06016465
What this study is testing
What is Dexamethasone Oral?
Dexamethasone Oral is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for migraine.
Also referred to as Decadron.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Meet ICHD-3 Migraine Headache Criteria
- Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2
- Nerve block performed with bupivacaine 0.5%
You likely can't join if
- Head trauma
- Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)
- Headache in the setting of viral syndrome
- Chronically on steroids
- Known allergy to dexamethasone
- Unable to reach the patient by phone or text for follow-up
See the full eligibility criteria
- Meet ICHD-3 Migraine Headache Criteria
- Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2
- Nerve block performed with bupivacaine 0.5%
- Head trauma
- Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)
- Headache in the setting of viral syndrome
- Chronically on steroids
- Known allergy to dexamethasone
- Unable to reach the patient by phone or text for follow-up
- Gestational diabetes or other uncontrolled diabetes
- Known to be immunocompromised
The study team makes the final eligibility decision.
Where it's taking place
- El Paso, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include El Paso, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.