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New treatment option for Diffuse Glioma
Official title A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma
ClinicalTrials.gov ID: NCT06016452
What this study is testing
What is Chlorophyllin?
Chlorophyllin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for diffuse glioma.
Also referred to as Stratum A (Symptomatic), Stratum A (Asymptomatic).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Diffuse gliomas are common tumors involving the brain. They are usually treated by surgery followed by radiation and chemotherapy.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Histological diagnosis of diffuse glioma.
- Radionecrosis on imaging with new neurological symptoms/ worsening of prior deficits (Stratum A) or
- without new symptoms (Stratum B).
- Karnofsky Performance Scale (KPS) ≥ 50.
You likely can't join if
- No tissue diagnosis.
- KPS\< 50.
- Disease progression
- Contraindications to corticosteroids.
- Altered mental status with deficits in understanding or inability to consent to the study.
- Brainstem glioma
See the full eligibility criteria
- Histological diagnosis of diffuse glioma.
- Radionecrosis on imaging with new neurological symptoms/ worsening of prior deficits (Stratum A) or
- without new symptoms (Stratum B).
- Karnofsky Performance Scale (KPS) ≥ 50.
- No tissue diagnosis.
- KPS\< 50.
- Disease progression
- Contraindications to corticosteroids.
- Altered mental status with deficits in understanding or inability to consent to the study.
- Brainstem glioma
- Indeterminate for radionecrosis vs disease progression
- Prior treatment with bevacizumab (either for disease progression or radionecrosis)
The study team makes the final eligibility decision.
Where it's taking place
- Mumbai, Maharashtra, India
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Mumbai, Maharashtra, India. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.