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New treatment option for Acute Respiratory Distress Syndrome
Official title Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
ClinicalTrials.gov ID: NCT06014138
What this study is testing
What is Propofol?
Propofol is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for acute respiratory distress syndrome.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 17 and older
You may be able to join if
- Adult patients admitted to the Intensive Care Unit (ICU)
- ARDS
- Invasive mechanical ventilation (IMV)
- Spontaneous breathing in pressures support mode (PSV) for less than or equal to 48 hours
- Sedated with intravenous sedation (ie. propofol and / or midazolam and fentanyl or alternate short acting opioid)
You likely can't join if
- Personal or family history of malignant hyperpyrexia
- Known or suspected elevated intracranial pressure
- High dose vasopressors (ie. Noradrenaline \> 0.3mcg/kg/min or equivalent)
- Contra-indication to oesophageal balloon (i.e. oesophageal / upper gastro-intestinal pathology)
- Pregnancy
- High dose oral sedatives (e.g. benzodiazepines) or opioids (e.g. oxycodone / oral morphine) which may affect respiratory drive
See the full eligibility criteria
- Adult patients admitted to the Intensive Care Unit (ICU)
- ARDS
- Invasive mechanical ventilation (IMV)
- Spontaneous breathing in pressures support mode (PSV) for less than or equal to 48 hours
- Sedated with intravenous sedation (ie. propofol and / or midazolam and fentanyl or alternate short acting opioid)
- Anticipated to remain on IMV and PSV and with a stable sedation score for a further 24 hours without planned sedation interruption / spontaneous breathing trial or other significant change in the level of ventilator...
- Not receiving / anticipated to receive paralysis
- In supine position
- Personal or family history of malignant hyperpyrexia
- Known or suspected elevated intracranial pressure
- High dose vasopressors (ie. Noradrenaline \> 0.3mcg/kg/min or equivalent)
- Contra-indication to oesophageal balloon (i.e. oesophageal / upper gastro-intestinal pathology)
- Pregnancy
- High dose oral sedatives (e.g. benzodiazepines) or opioids (e.g. oxycodone / oral morphine) which may affect respiratory drive
The study team makes the final eligibility decision.
Where it's taking place
- London, London, United Kingdom
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 17 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.