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New treatment option for Vasoconstriction
Official title Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
ClinicalTrials.gov ID: NCT05997732
What this study is testing
What is Phenylephrine Hydrochloride?
Phenylephrine Hydrochloride is an investigational medicine, being studied as a potential treatment for vasoconstriction.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Between ages 18-40 years
- No diagnosed medical history of cardiovascular, respiratory, nervous system, or metabolic disease.
- Females must be pre-menopausal.
- Prior to study visit: abstained from caffeine, alcohol, strenuous exercise, and medication not taken regularly for at least 12 hours.
You likely can't join if
- Current diagnosis of cardiovascular, respiratory, nervous system, or metabolic disease that may impact blood pressure regulation. This will be...
- Participants with bleeding or clotting disorders, or those currently taking blood thinners.
- Participants currently taking beta-agonist inhalers i.e. Ventolin (at least not in the last 24 hours).
- Females who are pregnant, confirmed by a pregnancy test.
- Females who have are less than 1 year postpartum or are breastfeeding.
- Females who are post-menopausal.
See the full eligibility criteria
- Between ages 18-40 years
- No diagnosed medical history of cardiovascular, respiratory, nervous system, or metabolic disease.
- Females must be pre-menopausal.
- Prior to study visit: abstained from caffeine, alcohol, strenuous exercise, and medication not taken regularly for at least 12 hours.
- Current diagnosis of cardiovascular, respiratory, nervous system, or metabolic disease that may impact blood pressure regulation. This will be assessed on a case-by-case basis by the study physician.
- Participants with bleeding or clotting disorders, or those currently taking blood thinners.
- Participants currently taking beta-agonist inhalers i.e. Ventolin (at least not in the last 24 hours).
- Females who are pregnant, confirmed by a pregnancy test.
- Females who have are less than 1 year postpartum or are breastfeeding.
- Females who are post-menopausal.
- Participants that are classified as obese (body mass index \> 30 kg ⋅ m2).
- Have a history of smoking regularly in the last 6 months (but nicotine substitutes (i.e. patch, gum) are not an exclusion criteria).
- Those with a known allergy to sulfites, or other components of the supplied solution of study drugs.
- Participants taking medications that are contraindicated with any of the study drugs, such as monoamine oxidase (MAO) inhibitors or tricyclic antidepressants.
- Participants who have not adhered to the pre-testing guidelines related to diet, alcohol or exercise will not be excluded, but will be rescheduled for a different day. This is to reduce experimental variability.
The study team makes the final eligibility decision.
Where it's taking place
- Edmonton, Alberta, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Edmonton, Alberta, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.