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New treatment option for Neuroendocrine Tumors
Official title Trial of Nab-sirolimus in Patients With Well-differentiated Neuroendocrine Tumors (NETs) of the Gastrointestinal Tract, Lung, or Pancreas Who Have Not Received Prior Treatment With mTOR Inhibitors
ClinicalTrials.gov ID: NCT05997056
What this study is testing
What is nab-sirolimus?
nab-sirolimus is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for neuroendocrine tumors.
Also referred to as ABI-009.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- A Phase 2 multi-center, open-label, single arm study of nab-sirolimus in patients with well-differentiated neuroendocrine tumors (NETs) of the gastrointestinal tract, lung, or pancreas who have not received prior treatment with mTOR inhibitors
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients with functional or non-functional, well-differentiated, locally advanced unresectable or metastatic NETs of the GI tract, lung, or pancreas...
- Patients with functional NETs may enroll if:
- the patient has been on a stable dose of an somatostatin analogs for ≥12 weeks and
- the patient has experienced disease progression while on stable somatostatin analogs dose
- Patients must have 1 or more measurable target lesions by RECIST v1.1
You likely can't join if
- Prior treatment with mTOR inhibitors including nab-sirolimus Note: Patients who have previously received locoregional or liver-directed therapies...
- Patients with functional NETs who are experiencing uncontrolled symptoms attributed to hormones and other vasoactive substances secreted by the tumor
- Patients with inactivating TSC1 or TSC2 alterations (based on tissue or liquid NGS)
- Severe (Grade ≥3) ongoing infection requiring parenteral or oral anti-infective treatment, either ongoing or completed ≤7 days prior to enrollment
- Patients who have any severe and/or uncontrolled medical or psychiatric conditions or other conditions that could affect their participation...
- Known or suspected brain metastases
See the full eligibility criteria
- Patients with functional or non-functional, well-differentiated, locally advanced unresectable or metastatic NETs of the GI tract, lung, or pancreas who have received 2 or less prior lines of therapy excluding...
- Patients with functional NETs may enroll if:
- the patient has been on a stable dose of an somatostatin analogs for ≥12 weeks and
- the patient has experienced disease progression while on stable somatostatin analogs dose
- Patients must have 1 or more measurable target lesions by RECIST v1.1
- Age: 18 years or older
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 or Karnofsky Performance Status (KPS) ≥80
- Adequate liver function:
- Total bilirubin ≤1.5 × upper limit of normal (ULN) (unless due to Gilbert's syndrome or attributable to liver metastases, then ≤3 × ULN)
- Aspartate aminotransferase (AST) and alanine transaminase (ALT) ≤2.5 × ULN (≤5 × ULN if attributable to liver metastases)
- Adequate renal function: creatinine clearance ≥30 mL/min, Cockcroft-Gault creatinine clearance = ((140-age) × weight[kg]) / (72 × serum creatinine [mL/min]) × 0.85, if female.
- Adequate hematologic parameters:
- Absolute neutrophil count (ANC) ≥1.0 × 10\^9/L (growth factor support allowed)
- Platelet count ≥100,000/mm\^3 (100 × 10\^9/L) (transfusion and/or growth factor support allowed)
- Hemoglobin ≥8.0 g/dL (transfusion and/or growth factor support allowed)
- Fasting serum triglyceride must be ≤300 mg/dL; fasting serum cholesterol must be less than or equal to 350 mg/dL
- Minimum of 4 weeks since any major surgery, completion of radiation, and adequately recovered from the acute toxicities of any prior therapy, including neuropathy, to Grade ≤1
- Male or non-pregnant and non-breastfeeding female:
- Females of childbearing potential must agree to use effective contraception or abstinence without interruption from 28 days prior to starting study medication throughout 3 months after last dose of study medication and...
- Male patients must agree not to donate sperm and must practice abstinence or agree to use a condom during sexual contact with a pregnant female or a female of childbearing potential while participating in the study and...
- Sexual abstinence is considered a highly effective contraceptive method only if defined as refraining from heterosexual intercourse from 28 days prior to starting study medication throughout 3 months after last dose of...
- The patient or the patient's legal guardian(s) understand(s) and sign(s) the informed consent
- Willingness and ability to comply with scheduled visits, laboratory tests, and other study procedures
- Patients with a known history of human immunodeficiency virus (HIV) infection are eligible if:
- There has been no acquired immunodeficiency syndrome (AIDS)-defining opportunistic infection in 12 months prior to enrollment.
- The patient has been receiving an antiretroviral therapy regimen for ≥4 weeks and the HIV viral load is \<400 copies/mL prior to enrollment.
- Antiretroviral therapy regimen does not include strong cytochrome (CYP)3A4 inhibitors or inducers
- Prior treatment with mTOR inhibitors including nab-sirolimus Note: Patients who have previously received locoregional or liver-directed therapies (radiofrequency or microwave ablation, transarterial chemoembolization...
- Patients with functional NETs who are experiencing uncontrolled symptoms attributed to hormones and other vasoactive substances secreted by the tumor
- Patients with inactivating TSC1 or TSC2 alterations (based on tissue or liquid NGS)
- Severe (Grade ≥3) ongoing infection requiring parenteral or oral anti-infective treatment, either ongoing or completed ≤7 days prior to enrollment
- Patients who have any severe and/or uncontrolled medical or psychiatric conditions or other conditions that could affect their participation including:
- Known or suspected brain metastases
- Severe heart disease defined as unstable angina pectoris, NYHA Class III or IV congestive heart failure, myocardial infarction ≤6 months prior to first study treatment, serious uncontrolled cardiac arrhythmia or any...
- Severe lung disease defined as a diffusing capacity for carbon monoxide that is ≤50% of normal predicted value and/or an O2 saturation ≤88% at rest on room air (Note: Spirometry and pulmonary function tests are not...
- Nonmalignant medical illnesses that are uncontrolled or whose control may be jeopardized by the treatment with the study therapy
- A history of malignancies other than the one under treatment unless the patient is disease-free for more than 5 years from diagnosis. Controlled non-melanoma skin cancers, carcinoma in situ of the cervix, resected...
- Uncontrolled hypertension (systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥100 mmHg)
- Patients with history of interstitial lung disease and/or pneumonitis, or pulmonary hypertension
- Active Hepatitis B and/or Hepatitis C infection and detectable viral load despite antiviral therapy.
- Required use of concomitant medications with strong CYP3A4 interactions (induction or inhibition) should be discontinued (strong inhibitors include ketoconazole, itraconazole, voriconazole, erythromycin, clarithromycin...
The study team makes the final eligibility decision.
Where it's taking place
- Newport Beach, California, United States
- Denver, Colorado, United States
- Dallas, Texas, United States
- Milwaukee, Wisconsin, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Newport Beach, California, United States; Denver, Colorado, United States; Dallas, Texas, United States; Milwaukee, Wisconsin, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.