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New treatment option for Low-grade Glioma
Official title CEST in Low-grade Glioma Study
ClinicalTrials.gov ID: NCT05996653
What this study is testing
- What it's testing
- Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic "Saturation Transfer" (ST)-MRI to evaluate LGG tumour progression and aims to predict early changes in LGG.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 12 and older
You may be able to join if
- Be at least 12 years of age;
- Diagnosed with:
- Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or...
- Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation
- No contraindications to MRI;
You likely can't join if
- Need for upfront post-surgical treatment with either chemotherapy and/or radiation therapy
- Pregnancy
See the full eligibility criteria
- Be at least 12 years of age;
- Diagnosed with:
- Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or clinical findings; or
- Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation
- No contraindications to MRI;
- eGFR \> 30 ml/min;
- No prior chemotherapy or radiation therapy;
- No need for upfront treatment (surgery, chemotherapy, and/or radiation therapy)
- Followed at either Sunnybrook Health Sciences Centre or at St Michael's Hospital
- Need for upfront post-surgical treatment with either chemotherapy and/or radiation therapy
- Pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 12 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.