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New treatment option for Respiratory Failure
Official title HYPoxaEmic Respiratory Failure and Awake Prone Ventilation
ClinicalTrials.gov ID: NCT05990101
What this study is testing
- What it's testing
- The goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patients admitted to intensive care unit for acute hypoxemic respiratory failure.
- Acute hypoxemic respiratory failure is defined by respiratory rate ≥25 breaths/min, and partial pressure of oxygen in the arterial blood...
- Informed consent
You likely can't join if
- impaired consciousness - Glasgow coma score \<14;
- inability to cooperate or prone position intolerance;
- immediate indications for endotracheal intubation;
- patients with do-not-intubate order at time of inclusion;
- patients with contraindication to high flow oxygen therapy (HFOT) or non-invasive ventilation (NIV);
- Partial pressure of carbon dioxide (PaCO2) above 50 mm Hg and quantitative measure of the acidity (pH) \<7,3;
See the full eligibility criteria
- Adult patients admitted to intensive care unit for acute hypoxemic respiratory failure.
- Acute hypoxemic respiratory failure is defined by respiratory rate ≥25 breaths/min, and partial pressure of oxygen in the arterial blood (PaO2)/fraction of inspired oxygen (FiO2) ≤300 mm Hg or oxygen saturation...
- Informed consent
- impaired consciousness - Glasgow coma score \<14;
- inability to cooperate or prone position intolerance;
- immediate indications for endotracheal intubation;
- patients with do-not-intubate order at time of inclusion;
- patients with contraindication to high flow oxygen therapy (HFOT) or non-invasive ventilation (NIV);
- Partial pressure of carbon dioxide (PaCO2) above 50 mm Hg and quantitative measure of the acidity (pH) \<7,3;
- vasopressor dose \>0.3 µg/kg/min of norepinephrine-equivalent to maintain systolic blood pressure \>90 mmHg;
- Covid-19 positive
The study team makes the final eligibility decision.
Where it's taking place
- Kaunas, Lithuania
- Vilnius, Lithuania
- London, United Kingdom
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kaunas, Lithuania; Vilnius, Lithuania; London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.