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New treatment option for Depression
Official title RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
ClinicalTrials.gov ID: NCT05977439
What this study is testing
- What it's testing
- In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Study 1 (Healthy Participants)
- Age 18-65 years
- Medically and psychiatrically healthy with no history of psychiatric or neurological disorders
- English-speaking
- Capacity to provide informed consent
You likely can't join if
- Any current or past psychiatric diagnosis
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Substance use disorder (excluding nicotine or caffeine)
See the full eligibility criteria
- Study 1 (Healthy Participants)
- Age 18-65 years
- Medically and psychiatrically healthy with no history of psychiatric or neurological disorders
- English-speaking
- Capacity to provide informed consent
- Willingness and ability to complete study procedures
- Negative pregnancy test for participants of childbearing potential
- Any current or past psychiatric diagnosis
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Substance use disorder (excluding nicotine or caffeine)
- Pregnancy or plans to become pregnant during study participation
- Inability to complete study procedures Studies 2, 3, and 4 (Participants With Depression) Inclusion Criteria:
- Age 18-65 years
- Current diagnosis of Major Depressive Disorder (MDD)
- Depression severity consistent with study criteria (e.g., HAM-D ≥17)
- No history of psychotic or bipolar disorders
- English-speaking
- Capacity to provide informed consent
- Willingness and ability to complete study procedures
- Negative pregnancy test for participants of childbearing potential Exclusion Criteria:
- Neurological disorders or history of central nervous system disease
- History of seizure or epilepsy or use of medications that lower seizure threshold
- Significant head injury or loss of consciousness
- Implanted metal or contraindications to MRI or TMS
- Substance use disorder (excluding nicotine or caffeine)
- Current participation in another treatment clinical trial
- Pregnancy or plans to become pregnant during study participation
- Any condition that would interfere with safe participation or completion of study procedures
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.