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New treatment option for Nutritional and Metabolic Diseases
Official title Blood Lipid Responses to Diet Macronutrients
ClinicalTrials.gov ID: NCT05973539
What this study is testing
- What it's testing
- The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged ≥18 to ≤65 years
- Body mass index (BMI) ≥19 to ≤35 kg/m2
- No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.
- Weight stable for the previous 3 months
You likely can't join if
- Aged \ 65 years
- BMI \ 35 kg/m2
- A blood haemoglobin \<135 mg/dL for men and \<120 mg/dL for women
- Donated (or lost) ≥250 mL of blood in the previous two months
- On a weight loss diet or decreased their body weight by \>5% in the previous 3 months
- Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat -...
See the full eligibility criteria
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged ≥18 to ≤65 years
- Body mass index (BMI) ≥19 to ≤35 kg/m2
- No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism.
- Weight stable for the previous 3 months
- Aged \ 65 years
- BMI \ 35 kg/m2
- A blood haemoglobin \<135 mg/dL for men and \<120 mg/dL for women
- Donated (or lost) ≥250 mL of blood in the previous two months
- On a weight loss diet or decreased their body weight by \>5% in the previous 3 months
- Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat - low-carbohydrate diet)
- Have increased their body weight by \>5% in the previous 3 months
- Any metabolic condition or relevant drug therapy
- Current smoker
- History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women)
- History of albumin allergy.
- Pregnant or nursing mothers
- History of severe claustrophobia
The study team makes the final eligibility decision.
Where it's taking place
- Oxford, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Oxford, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.