BridgeMD
New treatment option for Gulf War Illness
Official title Mechanisms of Gulf War Illness
ClinicalTrials.gov ID: NCT05972291
What this study is testing
- What it's testing
- Many veterans with Gulf War Illness developed chronic gastrointestinal symptoms during their deployment to the Persian Gulf. The pathophysiologic mechanisms of these chronic gastrointestinal symptoms are not well understood but cause significant morbidity in veterans.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Veterans 18-65 years old with GWI and chronic GI symptoms (abdominal pain, diarrhea, bloating) that started during their deployment in the Persian...
- Veterans 18-65 years old with GWI and chronic GI symptoms (abdominal pain, diarrhea, bloating)
- increased intestinal permeability on the lactulose/mannitol permeability test (ratio \>0.07)
- able and willing to cooperate with the study
You likely can't join if
- current participation in another research protocol or unable to give informed consent
- women with a positive urine pregnancy test or breastfeeding
- history of inflammatory bowel disease, lactose intolerance and/or celiac sprue
- \+ hydrogen breath test for bacterial overgrowth
- \+ anti-endomysial antibody titer
- use of NSAIDs 2 weeks before or during the study
See the full eligibility criteria
- Veterans 18-65 years old with GWI and chronic GI symptoms (abdominal pain, diarrhea, bloating) that started during their deployment in the Persian Gulf
- Veterans 18-65 years old with GWI and chronic GI symptoms (abdominal pain, diarrhea, bloating)
- increased intestinal permeability on the lactulose/mannitol permeability test (ratio \>0.07)
- able and willing to cooperate with the study
- current participation in another research protocol or unable to give informed consent
- women with a positive urine pregnancy test or breastfeeding
- history of inflammatory bowel disease, lactose intolerance and/or celiac sprue
- \+ hydrogen breath test for bacterial overgrowth
- \+ anti-endomysial antibody titer
- use of NSAIDs 2 weeks before or during the study
- known allergy to glutamine or whey protein
- abdominal surgery except for removal of gallbladder, uterus, or appendix \>6 months prior to entry into the study
- Abnormal serum BUN and/or creatinine
- Mannitol recovery out of the normal range of 5-25 U/g
- history of kidney disease
- allergies to monosodium glutamate
- current use of anti-seizure medications
The study team makes the final eligibility decision.
Where it's taking place
- Memphis, Tennessee, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Memphis, Tennessee, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.