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New treatment option for Lynch Syndrome
Official title CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome
ClinicalTrials.gov ID: NCT05963191
What this study is testing
- What it's testing
- Lynch syndrome (LS) is the most common genetic predisposition syndrome for colorectal cancer (CRC), responsible for around 2-4% of cancers. It is characterized by a pathogenic germline mutation in one of the DNA mismatch repair genes (path\_MMR) MLH1, MSH2, MSH6, PMS2 or a deletion in the 3' region of the Epcam gene.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90
You may be able to join if
- Confirmed pathogenic mutation (path\_MLH1, path\_MSH2, path\_MSH6, path\_PMS2, path\_EpCAM)
- Male or female of legal age at time of colonoscopy prescription.
- Patient agreeing to participate in the study
- Person affiliated with or benefiting from a social security scheme
- Free, informed and express consent
You likely can't join if
- Patient undergoing total colectomy with ileoanal or ileosigmoid anastomosis
- Patient with a history of Crohn's disease or ulcerative colitis
- Patients with a known allergy or intolerance to polyethylene glycol and ascorbic acid.
- Patients unable to undergo fractionated colonic preparation
- Inadequate colonic preparation: Boston sub-score \<2 per segment
- Patient under guardianship or protected person
See the full eligibility criteria
- Confirmed pathogenic mutation (path\_MLH1, path\_MSH2, path\_MSH6, path\_PMS2, path\_EpCAM)
- Male or female of legal age at time of colonoscopy prescription.
- Patient agreeing to participate in the study
- Person affiliated with or benefiting from a social security scheme
- Free, informed and express consent
- Patient undergoing total colectomy with ileoanal or ileosigmoid anastomosis
- Patient with a history of Crohn's disease or ulcerative colitis
- Patients with a known allergy or intolerance to polyethylene glycol and ascorbic acid.
- Patients unable to undergo fractionated colonic preparation
- Inadequate colonic preparation: Boston sub-score \<2 per segment
- Patient under guardianship or protected person
- Patient who does not understand French or cannot read
- Person not affiliated to a Social Security system.
- Pregnant women
The study team makes the final eligibility decision.
Where it's taking place
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Paris, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.