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New treatment option for Schizophrenia
Official title Restoring Spindle and Thalamocortical Efficiency in Early-Course Schizophrenia Patients Using Auditory Stimulation
ClinicalTrials.gov ID: NCT05956951
What this study is testing
- What it's testing
- The purpose of this research is to identify differences in brain activity during sleep between health individuals and individuals with schizophrenia, schizophreniform, or schizoaffective disorder. This study will also investigate whether tones played during deep sleep can enhance specific features of sleep and whether enhancing such features is related to an improvement in cognitive performance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Early-course schizophrenia (EC-SCZ):
- ages 18-40 years
- current DSM-IV defined diagnosis of schizophrenia, schizophreniform or schizoaffective disorder, not drug-induced, with no previously reported...
- duration of ≤5 years from beginning of psychosis, defined by report of symptoms and/or history of treatment according to clinical guidelines employed...
- lifetime exposure to antipsychotic medications ≤5 years Healthy controls (HC):
You likely can't join if
- General exclusion criteria:
- DSM-IV intellectual disability
- significant head injury
- medical illness affecting brain function or structure
- pregnancy or postpartum (\<6 weeks after delivery or miscarriage)
- significant neurological disorder (e.g. seizure disorder)
See the full eligibility criteria
- Early-course schizophrenia (EC-SCZ):
- ages 18-40 years
- current DSM-IV defined diagnosis of schizophrenia, schizophreniform or schizoaffective disorder, not drug-induced, with no previously reported psychotic episode
- duration of ≤5 years from beginning of psychosis, defined by report of symptoms and/or history of treatment according to clinical guidelines employed in our University of Pittsburgh Medical Center (UPMC) psychoses...
- lifetime exposure to antipsychotic medications ≤5 years Healthy controls (HC):
- ages 18-40 years
- no lifetime history of psychiatric disorders
- no first-degree family history of schizophrenia spectrum disorder or mood disorder with psychotic features.
- General exclusion criteria:
- DSM-IV intellectual disability
- significant head injury
- medical illness affecting brain function or structure
- pregnancy or postpartum (\<6 weeks after delivery or miscarriage)
- significant neurological disorder (e.g. seizure disorder)
- inability to provide informed consent
- current or past co-morbidity for alcohol or psychoactive substance dependence
- substance abuse other than cannabis and/or alcohol within the past one year For EC-SCZ: a) a psychotic illness with a temporal relation to substance use or head injury For healthy controls (HC):
- difficult falling and/or staying asleep for more than half the nights of a week, on average
- diagnosis of sleep apnea or restless leg syndrome
- sleeping less than 5 hours or more than 10 hours daily, on average
The study team makes the final eligibility decision.
Where it's taking place
- Pittsburgh, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pittsburgh, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.