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New treatment option for Obsessive-Compulsive Disorder
Official title Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
ClinicalTrials.gov ID: NCT05940324
What this study is testing
What is Ketamine?
Ketamine is an investigational medicine, being studied as a potential treatment for obsessive-compulsive disorder.
Also referred to as Ketamine Hydrochloride, Ketalar.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Eligibility Criteria for Participants with OCD:
- Ages 18-65
- Meet the criteria for OCD diagnosis
- Failed at least 1 prior trial of standard first-line OCD treatment
- Agree to the following lifestyle modifications: comply with requirements for fasting prior to the Experimental Session, not enroll in any other...
You likely can't join if
- prior naltrexone or ketamine use/exposure
- Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician
- Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control
- the presence of metal in the body that is contraindicated for MRI scans Eligibility Criteria for Healthy Volunteers: Inclusion Criteria:
- Ages 18-65
- Able to provide informed consent Exclusion Criteria:
See the full eligibility criteria
- Eligibility Criteria for Participants with OCD:
- Ages 18-65
- Meet the criteria for OCD diagnosis
- Failed at least 1 prior trial of standard first-line OCD treatment
- Agree to the following lifestyle modifications: comply with requirements for fasting prior to the Experimental Session, not enroll in any other treatment clinical trials during the duration of the study, and commit to...
- Able to provide informed consent
- prior naltrexone or ketamine use/exposure
- Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician
- Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control
- the presence of metal in the body that is contraindicated for MRI scans Eligibility Criteria for Healthy Volunteers: Inclusion Criteria:
- Ages 18-65
- Able to provide informed consent Exclusion Criteria:
- current or past use of psychotropic medication
- pregnant or nursing females
- the presence of metal in the body that is contraindicated for MRI scans
The study team makes the final eligibility decision.
Where it's taking place
- Stanford, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Stanford, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.