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New treatment option for Flumazenil Adverse Reaction
Official title Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam
ClinicalTrials.gov ID: NCT05939674
What this study is testing
What is Flumazenil?
Flumazenil is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for flumazenil adverse reaction.
Also referred to as Flumazenil, Flunil, Bukwang Pharm Co., Ltd.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Remimazolam is a medication that has the advantage of a short half-life and reversibility with flumazenil. In clinical situations, the use of flumazenil for the reversal of sedation is common, but there is no precise indication for its administration.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 and older
You may be able to join if
- Patients over 65 years old scheduled for hip joint surgery
You likely can't join if
- Patients with impaired consciousness or delirium before surgery
- Patients who are hemodynamically unstable before surgery
- Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function
- Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours
- Patients with known allergy to benzodiazepine, flumazenil
- Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption
See the full eligibility criteria
- Patients over 65 years old scheduled for hip joint surgery
- Patients with impaired consciousness or delirium before surgery
- Patients who are hemodynamically unstable before surgery
- Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function
- Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours
- Patients with known allergy to benzodiazepine, flumazenil
- Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption
- Patients with hypersensitivity to Dextran40
- Patients who have been taking benzodiazepine for long term
- Patients with end stage renal disease requiring hemodialysis
- Patients with history of acute angle glaucoma
- Patients with alcohol or substance dependence
- ASA classification 4 or 5
The study team makes the final eligibility decision.
Where it's taking place
- Yangsan, Gyeongsangnam-do, South Korea
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Yangsan, Gyeongsangnam-do, South Korea. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.