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New treatment option for Chronic Histiocytic Intervillositis
Official title Exploration of Allograft Humoral Rejection in Chronic Histiocytic Intervillositis
ClinicalTrials.gov ID: NCT05936333
What this study is testing
- What it's testing
- Chronic histiocytic intervillositis (CHI) is a rare condition with an incidence of 5 in 10,000 pregnancies. This rare condition is associated with placental inflammatory lesions leading to severe and recurrent obstetrical complications: intrauterine growth retardation (IUGR), fetal death in utero and miscarriage.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Family
- Mother and father ≥ 18 years old
- For mothers in the CHI group :
- History of a normal pregnancy (full term, alive child) or IUGR/MFIU or miscarriage(s) or abortion followed by at least 1 obstetrical complication...
- Diagnosis of chronic histiocytic intervillitis made by placental anatomopathological examination with CD68+ marking
See the full eligibility criteria
- Family
- Mother and father ≥ 18 years old
- For mothers in the CHI group :
- History of a normal pregnancy (full term, alive child) or IUGR/MFIU or miscarriage(s) or abortion followed by at least 1 obstetrical complication such as IUGR, MFIU, miscarriage
- Diagnosis of chronic histiocytic intervillitis made by placental anatomopathological examination with CD68+ marking
- For the mothers of the antiphospholipid syndrom group
- History of miscarriage(s)
- Having an anti-phospholipid syndrome
- For mothers in the normal pregnancy group:
- Third consecutive pregnancy of normal course, at term (≥ 36 weeks of amenorrhea) with eutrophic child For the mother and father: o Consent to participate in the study and for the participation in the study of at least...
- For mothers in the normal pregnancy group: o Suspected or confirmed intra-amniotic infection
- For all the mothers:
- History of blood transfusion
- History of allogeneic organ transplantation
- For the mother and the father:
- Person under legal protection (guardianship, curatorship)
The study team makes the final eligibility decision.
Where it's taking place
- Clamart, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Clamart, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.