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New treatment option for End-Stage Kidney Disease
Official title CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
ClinicalTrials.gov ID: NCT05931276
What this study is testing
What is Metoprolol Succinate?
Metoprolol Succinate is an investigational medicine, being studied as a potential treatment for end-stage kidney disease.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- On hemodialysis
- Received one of the following beta blockers through the VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, bisoprolol
You likely can't join if
- Impaired decision-making capacity
- Patients not receiving carvedilol who have a history of asthma
- known hypersensitivity to any component of either drug
- Provider unwilling to sign a new medication order for a assigned by chance patient
- No surrogate consent will be allowed
The study team makes the final eligibility decision.
Where it's taking place
- Long Beach, California, United States
- Gainesville, Florida, United States
- Decatur, Georgia, United States
- Iowa City, Iowa, United States
- Boston, Massachusetts, United States
- Minneapolis, Minnesota, United States
- Omaha, Nebraska, United States
- Albuquerque, New Mexico, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Long Beach, California, United States; Gainesville, Florida, United States; Decatur, Georgia, United States; Iowa City, Iowa, United States; Boston, Massachusetts, United States; Minneapolis, Minnesota, United States and 2 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.