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New treatment option for Infection, Bacterial
Official title Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
ClinicalTrials.gov ID: NCT05914779
What this study is testing
- What it's testing
- Specific Aim : The specific aim is to conduct a randomized prospective clinical trial to determine whether no antibiotics in OHCA patients in the ED with very low likelihood of infection is non-inferior to early antibiotic treatment. Hypothesis a: 28-day all-cause mortality will be non-inferior in OHCA patients with very low likelihood of infection who do not receive antibiotic therapy compared with those who receive early antibiotic therapy Hypothesis b: There will be no difference in subsequent incidence of proven infections in the no antibiotics vs, early antibiotics groups Hypothesis c: There will be no difference in the length of ICU stay and overall hospital stay in the early antibiotics vs.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- ● Adults aged \>18 years, presenting to HGH ED after out-of-hospital cardiac arrest
- Patients with low likelihood of infection as per the definitions provided above
- Ability to obtain informed consent from the people or their next of kin/family member/legal surrogate in case of incapacitation due to sedation...
You likely can't join if
- Patients who have clear evidence of infection, as defined by criteria for the study.
- Patients who have received antibiotics within the last 1 week prior to admission.
- Patients with malignancy, except those who have been cured or in complete remission.
- Females with known pregnancy.
- Known immunocompromised states (including HIV/AIDS, transplant recipients on immunosuppressant drugs, long-term [\> 3 weeks of prednisone \>5mg/day...
- Patients on immunologic disease modifying agents (commonly known as "biologics")
See the full eligibility criteria
- ● Adults aged \>18 years, presenting to HGH ED after out-of-hospital cardiac arrest
- Patients with low likelihood of infection as per the definitions provided above
- Ability to obtain informed consent from the people or their next of kin/family member/legal surrogate in case of incapacitation due to sedation, mechanical ventilation, etc. In case the next of kin is not available, an...
- Patients who have clear evidence of infection, as defined by criteria for the study.
- Patients who have received antibiotics within the last 1 week prior to admission.
- Patients with malignancy, except those who have been cured or in complete remission.
- Females with known pregnancy.
- Known immunocompromised states (including HIV/AIDS, transplant recipients on immunosuppressant drugs, long-term [\> 3 weeks of prednisone \>5mg/day equivalent] steroid therapy).
- Patients on immunologic disease modifying agents (commonly known as "biologics")
- Patients considered "brain-dead" or "vegetative state"
- Patients transferred from another hospital, long term care facility or institution
- Neutropenia (total WBC \<1,500/mm3 or absolute neutrophil count of \<1,000/mm3)
The study team makes the final eligibility decision.
Where it's taking place
- Doha, Baladiyat ad Dawhah, Qatar
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Doha, Baladiyat ad Dawhah, Qatar. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.