BridgeMD
New treatment option for Postural Orthostatic Tachycardia Syndrome
Official title NC Testing in LC & POTS
ClinicalTrials.gov ID: NCT05914649
What this study is testing
- What it's testing
- Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Patients with diagnosis of Long COVID
- SARS-COV2 test positive
- Symptoms \> 12 weeks post COVID
- Subjective complaint of 'brain fog" or cognitive dysfunction
- Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
You likely can't join if
- Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
- An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
- Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during...
- Unable to give an informed consent.
See the full eligibility criteria
- Patients with diagnosis of Long COVID
- SARS-COV2 test positive
- Symptoms \> 12 weeks post COVID
- Subjective complaint of 'brain fog" or cognitive dysfunction
- Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
- Subjective complaint of 'brain fog" or cognitive impairment
- Healthy participants
- Without POTS or "brain fog"
- Age 18 to 60 years
- Female and Male
- Able to give an informed consent
- Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
- An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
- Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
- Unable to give an informed consent.
The study team makes the final eligibility decision.
Where it's taking place
- Calgary, Alberta, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Calgary, Alberta, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.