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New treatment option for Cushing Syndrome
Official title Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism
ClinicalTrials.gov ID: NCT05911620
What this study is testing
- What it's testing
- The main hypothesis of the HEPACORT study is that upon diagnosis of endogenous Cushing's syndrome, significant liver fibrosis may be present, particularly in the most severe forms of Cushing's syndrome. the HEPACORT study is the first exploratory study to assess the severity of liver fibrosis in patients with Cushing's syndrome or suspected of presenting by Magnetic Resonance Elastography (MRE).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- age ≥ 18 years old;
- Person affiliated to a social security scheme or beneficiary of such a scheme;
- Person having received complete information on the organization of the research and having signed informed consent;
- Person having carried out a preliminary clinical examination adapted to the research.
- Patients with Cushing's syndrome (for the Cushing's Syndrome group)
You likely can't join if
- Person having taken corticosteroid therapy for more than 3 months during the 2 years preceding inclusion;
- Person having received corticosteroid therapy of shorter duration with discontinuation less than one month before inclusion;
- Person having taken anticortisolic treatment for more than 3 months during the 2 years preceding inclusion;
- Person with chronic liver disease;
- Person with alcohol misuse, defined by a weekly consumption of more than 10 standard units;
- Person with a morphotype that does not allow an MRI examination to be performed;
See the full eligibility criteria
- age ≥ 18 years old;
- Person affiliated to a social security scheme or beneficiary of such a scheme;
- Person having received complete information on the organization of the research and having signed informed consent;
- Person having carried out a preliminary clinical examination adapted to the research.
- Patients with Cushing's syndrome (for the Cushing's Syndrome group)
- Patients with possible Cushing's syndrome (for the suspected Cushing's Syndrome group) defined as response to the dexamethasone supression test with 1 mg of Dexamethasone, with a plasma cortisol assay at 8 am between 18...
- Patients with metabolic syndrome (for the metabolic syndrome group)
- Person having taken corticosteroid therapy for more than 3 months during the 2 years preceding inclusion;
- Person having received corticosteroid therapy of shorter duration with discontinuation less than one month before inclusion;
- Person having taken anticortisolic treatment for more than 3 months during the 2 years preceding inclusion;
- Person with chronic liver disease;
- Person with alcohol misuse, defined by a weekly consumption of more than 10 standard units;
- Person with a morphotype that does not allow an MRI examination to be performed;
- Woman of childbearing age who does not have an effective means of contraception;
- Contraindication to performing an MRI examination.
- Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the French Public Health Code.
The study team makes the final eligibility decision.
Where it's taking place
- Nancy, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nancy, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.