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New treatment option for Neurogenic Orthostatic Hypotension
Official title CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study
ClinicalTrials.gov ID: NCT05908760
What this study is testing
- What it's testing
- Neurogenic orthostatic hypotension (nOH) is a chronic condition associated with increased cardiovascular risk and reduced quality of life. On standing, patients with nOH experience a large reduction in blood pressure (BP; at least ≥20/10mmHg, but often much more), which is often accompanied by debilitating symptoms and syncope.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100
You may be able to join if
- Age ≥18 years
- Male and Female
- Physician diagnosis of Neurogenic Orthostatic Hypotension
- Non-smokers.
- Able and willing to provide informed consent.
You likely can't join if
- Medical therapies or medications which could interfere with testing of autonomic function
- Pregnant or breast-feeding females
- people with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
- Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These...
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during...
See the full eligibility criteria
- Age ≥18 years
- Male and Female
- Physician diagnosis of Neurogenic Orthostatic Hypotension
- Non-smokers.
- Able and willing to provide informed consent.
- Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.
- Medical therapies or medications which could interfere with testing of autonomic function
- Pregnant or breast-feeding females
- people with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
- Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These include dementia, alcohol and/or drug abuse, cerebrovascular disease...
- Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.
The study team makes the final eligibility decision.
Where it's taking place
- Calgary, Alberta, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Calgary, Alberta, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.