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Compares treatment options for Acute Ischemic Stroke
Official title Radial Versus Femoral Access For Thrombectomy in Patients With Acute Basilar Artery Occlusion
ClinicalTrials.gov ID: NCT05903560
What this study is testing
- What it's testing
- Stroke is one of the most important diseases endangering the health and quality of life of Chinese people. Acute ischemic stroke (AIS) is commonly caused by cerebrovascular stenosis or occlusion.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Acute ischemic stroke in the posterior circulation confirmed by symptoms and imaging examinations.
- Basilar artery occlusion confirmed by computed tomographic angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction...
- Age ≥ 18 years.
- Time from symptom onset to randomization within 24 hours of the estimated time of basilar artery occlusion.
- Baseline NIHSS score ≥ 10 before randomization.
You likely can't join if
- Pre-stroke disability with mRS score ≥ 3.
- Pregnant or lactating women.
- Allergic to contrast agents or nitinol devices.
- Participation in other clinical trials.
- Systolic blood pressure \> 185 mmHg or diastolic blood pressure \> 110mmHg, and can not be controlled by antihypertensive drugs.
- Known genetic or acquired bleeding diathesis, lack of coagulation factors; or oral anticoagulant therapy with INR \> 1.7.
See the full eligibility criteria
- Acute ischemic stroke in the posterior circulation confirmed by symptoms and imaging examinations.
- Basilar artery occlusion confirmed by computed tomographic angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA).
- Age ≥ 18 years.
- Time from symptom onset to randomization within 24 hours of the estimated time of basilar artery occlusion.
- Baseline NIHSS score ≥ 10 before randomization.
- Intact dual circulation of the hand assessed by the modified Allen's test.
- Written informed consent from patients or their legally authorized representatives.
- Pre-stroke disability with mRS score ≥ 3.
- Pregnant or lactating women.
- Allergic to contrast agents or nitinol devices.
- Participation in other clinical trials.
- Systolic blood pressure \> 185 mmHg or diastolic blood pressure \> 110mmHg, and can not be controlled by antihypertensive drugs.
- Known genetic or acquired bleeding diathesis, lack of coagulation factors; or oral anticoagulant therapy with INR \> 1.7.
- Baseline lab values: blood glucose \ 400mg/dL (22.2 mmol/L), platelet count \< 50\ 109 /L, or hematocrit \< 25%.
- Life expectancy less than 1 year.
- Lost to follow-up within 90 days (e.g. no fixed residence, overseas patients, etc.).
- Acute ischemic stroke within 48 hours after percutaneous coronary intervention, cerebrovascular intervention, or major surgery (patients can be included if more than 48 hours).
- Clinical manifestations of central nervous system vasculitis.
- Premorbid nervous system diseases or mental disorders hindering the assessment of the disease.
- Diseases or anatomical abnormalities that make it difficult for radial or femoral artery puncture, sheath insertion or instrument delivery, such as local infection, anatomical abnormalities confirmed by ultrasound or...
The study team makes the final eligibility decision.
Where it's taking place
- Nanjing, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nanjing, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.