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New treatment option for Bordetella Pertussis, Whooping Cough
Official title Impact of Bacterial Expression and Immune Response in the Severity of Pertussis
ClinicalTrials.gov ID: NCT05897879
What this study is testing
What is Nasopharyngeal swab?
Nasopharyngeal swab is an investigational medicine, being studied as a potential treatment for bordetella pertussis, whooping cough.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The resurgence of pertussis is associated with an evolutionary mechanism under the pressure of current acellular vaccines, with a possible impact on vaccine effectiveness and disease expression. Little is known about the mechanisms involved in the clinical variability of pertussis, including its most severe malignant form observed in infants (mortality between 50-80%).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages up to 15
You may be able to join if
- be between the ages of 0 and 15 years inclusive
- be suspected of having pertussis by the physician in charge, with the prescription of a diagnostic PCR (pertussis PCR, which may be a syndromic PCR...
- be free of any pathology/treatment that may influence the immune response (autoimmune/inflammatory pathology or immune deficiency not listed above...
- Have received age-appropriate information and written assent or consent from their parents/legal guardians
- be affiliated with or benefiting from a social security plan
You likely can't join if
- Patient with any pathology/treatment that may influence the immune response (autoimmune/inflammatory pathology or immune deficiency not listed above...
- Use of antibiotics active against pertussis in the 24 hours preceding the sampling
- Delay between the result of the diagnostic sample (pertussis PCR) and the day of inclusion \> 48 hours
- Patient's condition that, in the opinion of the physician, is incompatible with the expanded/additional sampling(s) required by the study
- Infant with a weight \< 2.5 kg at the time of inclusion.
The study team makes the final eligibility decision.
Where it's taking place
- Bordeaux, France
- Colombes, France
- Créteil, France
- Lille, France
- Lyon, France
- Marseille, France
- Nantes, France
- Paris, France
- Rouen, France
- Saint-Maur-des-Fossés, France
- Toulouse, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, up to 15 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bordeaux, France; Colombes, France; Créteil, France; Lille, France; Lyon, France; Marseille, France and 5 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.