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New treatment option for Posttraumatic Stress Disorder (PTSD)
Official title A Neurosensory Account of Anxiety and Stress (Study 1)
ClinicalTrials.gov ID: NCT05895006
What this study is testing
- What it's testing
- This study will take a basic neuroscience approach to investigate pathological mechanisms underlying PTSD. Additionally, the study aims to identify how Transcranial Alternating Current Stimulation (tACS) brain stimulation can modulate and correct neural networks and related emotions of anxious arousal and hypervigilance, with the goal of assessing tACS brain stimulation technology as a novel intervention for symptoms of anxiety.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50. Healthy volunteers may be eligible.
You may be able to join if
- Right-handed
- With normal or corrected-to-normal vision and normal olfaction
- Between the ages of 18 and 50 years
- Meeting the tACS screening criteria (see List I below; e.g., lack of a serious head injury or loss of consciousness)
- Patients: Diagnosis of PTSD
You likely can't join if
- A history of diagnosis for a major medical illness (e.g., cancer, metabolic syndrome, cardiovascular disease, inflammatory disorders) or a...
- Patients: Concurrent Axis I diagnosis (depression, anxiety, and mild substance use disorder are allowed given their high comorbidity with PTSD).
- Healthy controls: A history of diagnosis for a DSM-5 Axis I disorder or current use of psychoactive medications.
- Severe psychiatric instability or severe situational life crises, including evidence of being actively suicidal or homicidal, or any behavior that...
- History of head trauma with unconsciousness (\> 5 minutes)
- Report that they regularly drink 3 or more alcoholic beverages a day.
See the full eligibility criteria
- Right-handed
- With normal or corrected-to-normal vision and normal olfaction
- Between the ages of 18 and 50 years
- Meeting the tACS screening criteria (see List I below; e.g., lack of a serious head injury or loss of consciousness)
- Patients: Diagnosis of PTSD
- Patients: If taking psychotropic medications, medication stability in the past 2 months
- If having mild substance use disorder (for patients) or occasional substance use, abstention from use 48 hours before the experiment.
- A history of diagnosis for a major medical illness (e.g., cancer, metabolic syndrome, cardiovascular disease, inflammatory disorders) or a neurological disorder (e.g., seizure, stroke, Parkinson's disease).
- Patients: Concurrent Axis I diagnosis (depression, anxiety, and mild substance use disorder are allowed given their high comorbidity with PTSD).
- Healthy controls: A history of diagnosis for a DSM-5 Axis I disorder or current use of psychoactive medications.
- Severe psychiatric instability or severe situational life crises, including evidence of being actively suicidal or homicidal, or any behavior that poses an immediate danger to self or others.
- History of head trauma with unconsciousness (\> 5 minutes)
- Report that they regularly drink 3 or more alcoholic beverages a day.
- Report that they are unable to abstain from substance use (including alcohol, nicotine, cannabis, amphetamines, narcotics, solvents, cocaine, hallucinogens, tranquilizers, barbiturates, etc.) or sleep medication for 48...
- Are on calcium channel blockers (e.g., verapamil, nifedipine) or alpha-blockers (e.g., prazosin, terazosin) and are unable to stop these medications for a 48-hour period prior to scanning (to exclude the impact of these...
- Failed Urine Drug Screening Test: A rapid urine screening test that utilizes monoclonal antibodies to detect elevated levels of specific drugs (including alcohol, amphetamines, benzodiazepines, barbiturates, cocaine...
- Pregnancy based on urine test. The safety of MR systems has not been established for fetuses
- Having electrically, magnetically, or mechanically activated implants (e.g., cardiac pacemakers), because the electromagnetic fields produced by the MR system may interfere with the operation of these devices.
The study team makes the final eligibility decision.
Where it's taking place
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Houston, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.