BridgeMD
New treatment option for Cannabis Use Disorder
Official title SCORE Emerging Adult Cannabis Use & Stress
ClinicalTrials.gov ID: NCT05885542
What this study is testing
What is Cannabidiol oral solution?
Cannabidiol oral solution is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for cannabis use disorder.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults. Given the dynamics at play in this critical stage when cannabis use is most prevalent, developmentally informed research is needed to guide tailored clinical interventions.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 25
You may be able to join if
- Able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments
- Meet DSM-5 criteria for CUD and report using cannabis at least five times weekly over the past month. While individuals may also meet criteria for...
- Age 18-25
- BMI between 18-30 (to decrease variability in CBD response and in endocannabinoid system measures)
- AST, ALT, and total bilirubin within the laboratory reference range of normal
You likely can't join if
- Females who are pregnant, nursing, or planning to become pregnant during the study.
- Current severe substance use disorder other than cannabis
- Current medications or supplements with clinically significant interactions with cannabidiol (per Lexicomp, this list includes Blasting, Doxorubicin...
- Current unstable psychiatric or medical disorder that would interfere with safety, compromise data integrity, or preclude reliable participation
- History of hypersensitivity to CBD, sesame, or sesame products
- Inability to comply with study procedures
See the full eligibility criteria
- Able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments
- Meet DSM-5 criteria for CUD and report using cannabis at least five times weekly over the past month. While individuals may also meet criteria for other mild substance use disorders, they must identify cannabis as their...
- Age 18-25
- BMI between 18-30 (to decrease variability in CBD response and in endocannabinoid system measures)
- AST, ALT, and total bilirubin within the laboratory reference range of normal
- Consent to alcohol abstinence for 12 hours prior to study visits, three days of cannabis abstinence as part of study procedures, and abstinence from all substances aside from cannabis, alcohol, and nicotine for the...
- Sexually active females of childbearing potential must agree to utilize an effective means of birth control.
- Consent to random assignment to CBD versus placebo
- Females who are pregnant, nursing, or planning to become pregnant during the study.
- Current severe substance use disorder other than cannabis
- Current medications or supplements with clinically significant interactions with cannabidiol (per Lexicomp, this list includes Blasting, Doxorubicin, Mavacamten, Pazopanib, Sirolimus, Topotecan, Vincristine, Afatinib...
- Current unstable psychiatric or medical disorder that would interfere with safety, compromise data integrity, or preclude reliable participation
- History of hypersensitivity to CBD, sesame, or sesame products
- Inability to comply with study procedures
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 25 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.