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New treatment option for Rectal Cancer
Official title Total Neoadjuvant Treatment Combined With Adaptive Radiotherapy for Rectal Cancer
ClinicalTrials.gov ID: NCT05883800
What this study is testing
- What it's testing
- Diarrhea was the most frequently reported severe adverse event in the treatment regime of pre-operative sequential short-course radiotherapy followed by chemotherapy (so called total neo-adjuvant treatment). This study therefore investigates the benefit of on-couch adaptation for locally advanced rectal cancer patients undergoing this treatment regime.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients with loco-regional advanced rectal adenocarcinoma with clinical indications for short-course with TNT chemotherapy i.e. having at least one...
- ECOG status ≤ 1
- Being willing and able to give full written consent for participation
You likely can't join if
- Previous rectal cancer treatment
- Previous irradiation to the treatment area e.g. prostate cancer
- Hip prosthesis
- Contraindications to MRI
- Pregnancy
- Abnormal DPYD genotype
See the full eligibility criteria
- Patients with loco-regional advanced rectal adenocarcinoma with clinical indications for short-course with TNT chemotherapy i.e. having at least one of the following T4a, CRM+ (≤1 mm), N1c, N2 or extramural vascular...
- ECOG status ≤ 1
- Being willing and able to give full written consent for participation
- Previous rectal cancer treatment
- Previous irradiation to the treatment area e.g. prostate cancer
- Hip prosthesis
- Contraindications to MRI
- Pregnancy
- Abnormal DPYD genotype
- Known contraindication to 5-FU, Capecitabine or Oxaliplatin as judged by the investigators
The study team makes the final eligibility decision.
Where it's taking place
- Bergen, Norway
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bergen, Norway. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.