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New treatment option for Fatigue
Official title The Role of the Brain in Mental and Physical Fatigue
ClinicalTrials.gov ID: NCT05880342
What this study is testing
What is Reboxetine Pill?
Reboxetine Pill is an investigational medicine, being studied as a potential treatment for fatigue.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to determine the role of brain neurotransmission in the onset of fatigue, identify the brain areas involved, and determine how brain activity and neuromuscular efficiency changes during onset of fatigue. Three different experimental studies (physical fatigue, mental fatigue and combined) will be performed with a randomized, single-blinded, placebo controlled, counter-balanced, cross-over design.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35. Healthy volunteers may be eligible.
You may be able to join if
- Healthy trained individuals (exercises at least 1x per week, no neurological, cardiovascular internal or musculoskeletal disorders of any kind)
- No use of chronic or occasional prescribed medication (except for contraceptives)
- Non-smoker
You likely can't join if
- Injuries of any kind in the past 6 months
- Pregnancy
- Specific food or drink allergies (e.g. lactose and/or gluten intolerance)
- Suffering from a chronic health condition (could be neurological, cardiovascular, internal and musculoskeletal)
- Participating in any concomitant care or research trials
- History of suffering from any mental/psychiatric disorders: Suffering from a higher risk of burn out, indicated by a total score of more than 2.59 on...
See the full eligibility criteria
- Healthy trained individuals (exercises at least 1x per week, no neurological, cardiovascular internal or musculoskeletal disorders of any kind)
- No use of chronic or occasional prescribed medication (except for contraceptives)
- Non-smoker
- Injuries of any kind in the past 6 months
- Pregnancy
- Specific food or drink allergies (e.g. lactose and/or gluten intolerance)
- Suffering from a chronic health condition (could be neurological, cardiovascular, internal and musculoskeletal)
- Participating in any concomitant care or research trials
- History of suffering from any mental/psychiatric disorders: Suffering from a higher risk of burn out, indicated by a total score of more than 2.59 on the Burn out assessment tool (BAT) Suffering from high general...
- Use of medication Chronic use with an exception for contraceptives Prescribed medication in between or before trials Use of non-prescribed occasional medication 24 hours prior each trial
- Use of caffeine and heavy efforts 24 hours prior each trial
- Suffering from colour vision deficiencies
- Not eating a standardized meal, the morning of each trial
The study team makes the final eligibility decision.
Where it's taking place
- Brussels, Brussels Capital, Belgium
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 35 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Brussels, Brussels Capital, Belgium. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.