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New treatment option for Patients With Ultra High Risk of Psychotic Transition
Official title Evaluation of Membrane Phospholipid and Energy Metabolism in Subjects at High Risk of Psychotic Transition
ClinicalTrials.gov ID: NCT05865652
What this study is testing
- What it's testing
- The management of schizophrenia is a major public health issue, due to its particularly disabling psychotic symptoms and their onset at an early age, typically in adolescents or young adults. The physiopathological hypothesis of an anomaly relating to the renewal of cell membranes and energy metabolism in schizophrenia was proposed as early as the 1930s.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 15 to 25. Healthy volunteers may be eligible.
You may be able to join if
- for the UHR group:
- Patient between 15 and 25 years old
- Patient fulfilling the UHR criteria objectified by the Comprehensive Assessment of At Risk Mental State scale (CAARMS) and by the social and...
- Patient with no contraindication to performing a 7T MRI examination
- Affiliated patient or beneficiary of a social security scheme.
You likely can't join if
- for the UHR group:
- Patient not at risk or already in a psychotic pathological process according to DSM-5 criteria.
- Patient already receiving antipsychotic treatment or whose background treatment was changed less than a month ago.
- Patient presenting an absolute contraindication to 7T MRI such as: foreign bodies (intracranial clips, vascular magnetic clips, cardiac or neural...
See the full eligibility criteria
- for the UHR group:
- Patient between 15 and 25 years old
- Patient fulfilling the UHR criteria objectified by the Comprehensive Assessment of At Risk Mental State scale (CAARMS) and by the social and professional functioning assessment scale (SOFAS) (the "Vulnerability" group...
- Patient with no contraindication to performing a 7T MRI examination
- Affiliated patient or beneficiary of a social security scheme.
- Free, informed consent, written and signed by the participant, the investigator and the legal representative if applicable (at the latest on the day of inclusion and before any examination required by the research). for...
- people aged 15 to 25 years old,
- healthy volunteer subject or subject to benefit from an imaging examination, not presenting the criteria of a mental health disorder objectified by a medical interview
- Subject with no contraindication to performing a 7T MRI examination
- Affiliated subject or beneficiary of a social security scheme.
- Free, informed and written consent signed by the participant, the investigator and the legal representative if applicable (at the latest on the day of inclusion and before any examination required by the research).
- for the UHR group:
- Patient not at risk or already in a psychotic pathological process according to DSM-5 criteria.
- Patient already receiving antipsychotic treatment or whose background treatment was changed less than a month ago.
- Patient presenting an absolute contraindication to 7T MRI such as: foreign bodies (intracranial clips, vascular magnetic clips, cardiac or neural pacemakers, stents, coils, implantable chamber, intracorporeal metallic...
The study team makes the final eligibility decision.
Where it's taking place
- Poitiers, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 15 years to 25 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Poitiers, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.