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New treatment option for Colorectal Cancer
Official title Postoperative Effects of Different Enterostomy Approaches
ClinicalTrials.gov ID: NCT05853094
What this study is testing
- What it's testing
- Exploring the effect of protective ileostomy compared with transverse colostomy on the occurrence of complications, the occurrence of serious side effects of adjuvant chemotherapy and disease recurrence in patients with low rectal cancer after radical surgery from the perspective of intestinal microecology.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Pathological confirmed adenocarcinoma of the rectum;
- Patients age between 18-80;
- Baseline AJCC stage I-III: cT1-4N0-2M0 (AJCC-8 version);
- Eastern Cooperative Oncology Group (ECOG) physical status score of 0 to 2;
- Patients voluntarily sign informed consent.
You likely can't join if
- Other types of rectal cancer (adenosquamous carcinoma, squamous carcinoma, neuroendocrine tumors, clear cell carcinoma, spindle cell carcinoma...
- Combination of rectal cancer with multiple carcinomas;
- Pre-operative presence of acute and chronic infectious diseases or foci of infection;
- Intraoperative radical surgery was not performed for various reasons；
- Colostomy was not performed at the same time as the radical rectal cancer surgery;
- Combined with intestinal obstruction, intestinal perforation, intestinal bleeding, peritonitis, etc. requiring emergency surgery;
See the full eligibility criteria
- Pathological confirmed adenocarcinoma of the rectum;
- Patients age between 18-80;
- Baseline AJCC stage I-III: cT1-4N0-2M0 (AJCC-8 version);
- Eastern Cooperative Oncology Group (ECOG) physical status score of 0 to 2;
- Patients voluntarily sign informed consent.
- Other types of rectal cancer (adenosquamous carcinoma, squamous carcinoma, neuroendocrine tumors, clear cell carcinoma, spindle cell carcinoma, undifferentiated carcinoma);
- Combination of rectal cancer with multiple carcinomas;
- Pre-operative presence of acute and chronic infectious diseases or foci of infection;
- Intraoperative radical surgery was not performed for various reasons；
- Colostomy was not performed at the same time as the radical rectal cancer surgery;
- Combined with intestinal obstruction, intestinal perforation, intestinal bleeding, peritonitis, etc. requiring emergency surgery;
- Metastatic cancer;
- Serious heart, lung, liver and kidney disease, can not tolerate surgery;
- Active liver disease or abnormal liver function with ALT, AST and TBIL more than 2 times the upper limit of normal values;
- Renal impairment with Cr ≥ 2 times the upper limit of normal or BUN ≥ 2 times the upper limit of normal;
- Blood leukocytes below the lower limit of normal value, or platelets below the lower limit of normal value, or with other blood system diseases;
- Pregnancy;
- Mental illness or serious intellectual disability who cannot describe their feelings correctly;
- Severe coagulation disorder, bleeding tendency;
- Patients with severe uncontrolled medical disease, recent history of myocardial infarction (within 3 months), uncontrolled severe hypertension and severe diabetes mellitus;
- Patients need to be on antibiotics/other probiotics for a long time.
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.