BridgeMD
New treatment option for Stroke
Official title Mechanisms of Open and Hidden Placebo in Stroke Recovery
ClinicalTrials.gov ID: NCT05832567
What this study is testing
- What it's testing
- This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adults with hemiparesis due to chronic stroke
- Stroke duration of 6 months or more
- Fugl-Meyer scale upper extremity motor assessment score of \> 11 and ≤ 56
- Pre-stroke disability (defined as a score of \< 3 on the Modified Rankin Scale)
- Age 18 or older
You likely can't join if
- Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex
- Unable to understand instructions
- TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump
- Concurrent unstable medical conditions
- A score of 24 or higher on the Hamilton Depression Rating Scale (HDRS)
- Joint or paretic extremity pain likely to interfere with assessments
See the full eligibility criteria
- Adults with hemiparesis due to chronic stroke
- Stroke duration of 6 months or more
- Fugl-Meyer scale upper extremity motor assessment score of \> 11 and ≤ 56
- Pre-stroke disability (defined as a score of \< 3 on the Modified Rankin Scale)
- Age 18 or older
- Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex
- Unable to understand instructions
- TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump
- Concurrent unstable medical conditions
- A score of 24 or higher on the Hamilton Depression Rating Scale (HDRS)
- Joint or paretic extremity pain likely to interfere with assessments
- Pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Cambridge, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Cambridge, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.