BridgeMD
Prevention study for Critical Illness
Official title Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
ClinicalTrials.gov ID: NCT05829317
What this study is testing
What is Magnesium sulfate?
Magnesium sulfate is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for critical illness.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years;
- Admitted to an ICU with one or more of the following:
- Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24...
- Vasopressor or inotropic support with an expected duration of \>24 hours
- Cardiac arrest
You likely can't join if
- Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for...
- Receiving IMV for airway protection only (for example, isolated head trauma)
- Active atrial fibrillation at the time of enrolment
- On oral or continuous infusion of Amiodarone
- Unlikely to survive \>24 hours or palliative patients
- Cardiac surgery patients
See the full eligibility criteria
- Age ≥18 years;
- Admitted to an ICU with one or more of the following:
- Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic)
- Vasopressor or inotropic support with an expected duration of \>24 hours
- Cardiac arrest
- Continuous cardiac monitoring.
- Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours
- Receiving IMV for airway protection only (for example, isolated head trauma)
- Active atrial fibrillation at the time of enrolment
- On oral or continuous infusion of Amiodarone
- Unlikely to survive \>24 hours or palliative patients
- Cardiac surgery patients
- Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
- Patients receiving dialysis
- Positive pregnancy test (females \<50 years old)
- Previously enrolled in this trial
- Treating physician refuses enrollment
The study team makes the final eligibility decision.
Where it's taking place
- Hamilton, Ontario, Canada
- Kingston, Ontario, Canada
- Ottawa, Ontario, Canada
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hamilton, Ontario, Canada; Kingston, Ontario, Canada; Ottawa, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.