BridgeMD
New treatment option for Obesity
Official title Metabolic Adaptations to Weight Loss With and Without Exercise
ClinicalTrials.gov ID: NCT05806801
What this study is testing
- What it's testing
- Study Purpose: The combination of caloric restriction and exercise is the most common first-line treatment for obesity-related disorders, yet we know very little about how these two very different treatments work together. A deeper understanding about mechanisms underlying the health benefits of adding exercise to a weight loss program will not only aid efforts to optimize more effective lifestyle interventions, but it can also uncover novel targets for the treatment/prevention of obesity-related diseases.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Age: 18-40
- Body Mass Index: 30-40 kg/m2
- Weight stable (±3kg for greater than or equal to about 2 months)
- No regularly planned exercise/physical activity
- Women must have regularly occurring menses and must be premenopausal
You likely can't join if
- EKG abnormalities
- Evidence/history of cardiovascular disease, diabetes or other metabolic disease
- Medications known to affect lipid or glucose metabolism
- Pregnant or lactating
- Tobacco or e-cigarette use
- Prior experience of hypersensitivity to insulin, human albumin, and potassium chloride injection.
See the full eligibility criteria
- Age: 18-40
- Body Mass Index: 30-40 kg/m2
- Weight stable (±3kg for greater than or equal to about 2 months)
- No regularly planned exercise/physical activity
- Women must have regularly occurring menses and must be premenopausal
- EKG abnormalities
- Evidence/history of cardiovascular disease, diabetes or other metabolic disease
- Medications known to affect lipid or glucose metabolism
- Pregnant or lactating
- Tobacco or e-cigarette use
- Prior experience of hypersensitivity to insulin, human albumin, and potassium chloride injection.
- Allergies/hypersensitivity to local anesthetics of the amide type (e.g., lidocaine)
- History of hyperkalemia or potential for developing hyperkalemia (including but not limited to taking drugs that may induce hyperkalemia such as cardiac glycosides or potassium sparing diuretics)
- Anti-coagulant medication (e.g., Coumadin, Rivaroxaban) and Lidocaine allergy/sensitivity are exclusion criteria for the biopsy procedure.
The study team makes the final eligibility decision.
Where it's taking place
- Ann Arbor, Michigan, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ann Arbor, Michigan, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.