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New treatment option for Obstructive Sleep Apnea
Official title Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea
ClinicalTrials.gov ID: NCT05804084
What this study is testing
What is Acetazolamide?
Acetazolamide is an investigational medicine, given as an once-weekly pill taken by mouth, being studied as a potential treatment for obstructive sleep apnea.
Also referred to as Diamox.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years
- Body mass index ≤ 35 kg/m2
- Untreated moderate/severe OSA (AHI ≥15/h)
You likely can't join if
- Substantial sleep hypoxemia (SpO2\ 10% of the monitoring time during the home sleep test, or for \>25% of the total sleep time during any of the...
- Abnormally low blood counts/electrolytes or renal function at baseline
- Use of OSA therapy during the past 1 month, or plans to urgently resume/(re)start clinical OSA therapy within 3 months
- Significant, uncontrolled cardiac, pulmonary, endocrine, renal, hepatic, neurocognitive, psychiatric, or urologic (e.g., kidney stones) disorder
- Other major sleep disorder (e.g., narcolepsy)
- Urgent need to initiate effective OSA therapy (i.e., Epworth sleepiness score \>18, commercial driver, prior sleep-related car accident, or based on...
See the full eligibility criteria
- Age ≥18 years
- Body mass index ≤ 35 kg/m2
- Untreated moderate/severe OSA (AHI ≥15/h)
- Substantial sleep hypoxemia (SpO2\ 10% of the monitoring time during the home sleep test, or for \>25% of the total sleep time during any of the in-laboratory studies)
- Abnormally low blood counts/electrolytes or renal function at baseline
- Use of OSA therapy during the past 1 month, or plans to urgently resume/(re)start clinical OSA therapy within 3 months
- Significant, uncontrolled cardiac, pulmonary, endocrine, renal, hepatic, neurocognitive, psychiatric, or urologic (e.g., kidney stones) disorder
- Other major sleep disorder (e.g., narcolepsy)
- Urgent need to initiate effective OSA therapy (i.e., Epworth sleepiness score \>18, commercial driver, prior sleep-related car accident, or based on MD judgment)
- Severe allergy to sulfa-drugs or taking another carbonic-anhydrase inhibitor (e.g., topiramate)
- Pregnancy/breastfeeding (current/planned)
- Prisoners
- Illicit substance abuse or \>2 standard drinks of alcohol/day
- Medications that may affect OSA or ventilatory control (e.g., opiates, sedatives)
- Thiazide/loop diuretic (risk of hypokalemia)
- Inability to give consent or follow procedures
- Safety concern based on MD judgment
The study team makes the final eligibility decision.
Where it's taking place
- La Jolla, California, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include La Jolla, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.