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New treatment option for Osteoarthritis, Knee
Official title The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty
ClinicalTrials.gov ID: NCT05800457
What this study is testing
- What it's testing
- Osteoarthritis (OA) is the most common joint disease, causing severe pain due to joint inflammation (synovitis). While total knee arthroplasty (TKA) is commonly performed to reduce pain, 20% of patients are dissatisfied with their outcome post-surgery.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 41 to 80
You may be able to join if
- Males or females over the age of 40 diagnosed with knee osteoarthritis
- Scheduled for first unilateral total knee arthroplasty
- Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment
- Referred to the Pre-Admission Clinic at University Hospital
You likely can't join if
- Bilateral, uni-compartmental, or revision total knee arthroplasty
- Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.)
- Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g. methotrexate...
- Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date
- Cannot read, write, or understand English (printed instructions are provided in English only)
- Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell...
See the full eligibility criteria
- Males or females over the age of 40 diagnosed with knee osteoarthritis
- Scheduled for first unilateral total knee arthroplasty
- Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment
- Referred to the Pre-Admission Clinic at University Hospital
- Bilateral, uni-compartmental, or revision total knee arthroplasty
- Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.)
- Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g. methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, TNF inhibitors, etc.) - note: Gout is...
- Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date
- Cannot read, write, or understand English (printed instructions are provided in English only)
- Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell phone, etc.).
- Cognitive impairment or psychological problems that preclude the ability to understand instructions
- Not able to follow up at routine standard of care post-operative visits
The study team makes the final eligibility decision.
Where it's taking place
- London, Ontario, Canada
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 41 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.