BridgeMD
Compares treatment options for Primary Hyperaldosteronism Due to Adrenal Adenoma
Official title Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment
ClinicalTrials.gov ID: NCT05797558
What this study is testing
What is Medical treatment (eplerenone)?
Medical treatment (eplerenone) is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for primary hyperaldosteronism due to adrenal adenoma.
Also referred to as Mineralocorticoid receptor antagonists.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a prospective randomized controlled trial where quality of life and the effectiveness of treatment will be evaluated in 80 patients with confirmed unilateral primary aldosteronism ,randomly assigned to be either treated surgically with unilateral adrenalectomy or to receive medical treatment with eplerenone.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Patients with confirmed unilateral PA
- Age 18-70 years
- Candidate for surgical treatment
- No contraindications for minimally invasive surgery or treatment with MRA
- Understands oral and written information and provides oral and written informed consent.
You likely can't join if
- Unwilling or unable to undergo surgery
- Unwilling to accept medical treatment for 12 months and not receiving standard treatment (surgery)
- Impaired renal function with eGFR \<45 ml/min/1,73m2
- P-cortisol \>138 nmol/L following 1-mg overnight dexamethasone suppression test.
The study team makes the final eligibility decision.
Where it's taking place
- Gothenburg, Sweden
- Stockholm, Sweden
- Umeå, Sweden
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Gothenburg, Sweden; Stockholm, Sweden; Umeå, Sweden. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.