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New treatment option for Mild Cognitive Impairment
Official title Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
ClinicalTrials.gov ID: NCT05795634
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question(s) it aims to answer are: Does the hormone response to acute stress predict the degree of cognitive impairment following acute stress?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 and older
You may be able to join if
- for people with Mild Cognitive Impairment (MCI)
- Age 60 and older
- Fluent English speaker
- Able to provide informed consent for study procedures
- Willing and able to return for 2-year-followup visit
You likely can't join if
- for people with MCI
- Current smoker
- Current or past history of major psychiatric illness, including schizophrenia, bipolar disorder, obsessive-compulsive disorder, post-traumatic stress...
- Neurological disorder, including Parkinson's disease, Huntington's disease
- Current or past history of immune disorder, including multiple sclerosis
- Current or past history of drug dependence
See the full eligibility criteria
- for people with Mild Cognitive Impairment (MCI)
- Age 60 and older
- Fluent English speaker
- Able to provide informed consent for study procedures
- Willing and able to return for 2-year-followup visit
- Willing and able to provide an informant who can participate in the screening and 2-year study visits
- BMI \>17 and \<30
- Meets clinical and cognitive criteria for mild cognitive impairment (MCI) using National Institute on Aging (NIA)/Alzheimer's Association 2011 criteria (see below)
- for people with MCI
- Current smoker
- Current or past history of major psychiatric illness, including schizophrenia, bipolar disorder, obsessive-compulsive disorder, post-traumatic stress disorder
- Neurological disorder, including Parkinson's disease, Huntington's disease
- Current or past history of immune disorder, including multiple sclerosis
- Current or past history of drug dependence
- Treatment within the last six months with: neuroleptics, sedative hypnotics, or glucocorticoids
- History of head injury with loss of consciousness for more than ½ hour, stroke, or seizure
- General surgery within the last 3 months
- Sensory impairment (poor vision or hearing) significant enough to interfere with ability to provide valid cognitive test data Clinical and Cognitive Criteria for MCI due to AD
- Cognitive concern reflecting a change in cognition reported by patient or informant or clinician (i.e., historical or observed evidence of decline over time)
- Objective evidence of impairment in one or more cognitive domains, typically including memory (i.e., formal or bedside testing to establish level of cognitive function in multiple domains)
- Preservation of independence in functional abilities
- Not demented
- Etiology of MCI consistent with AD pathophysiological process Inclusion Criteria for Study Partners
- Age 21 or older
- Able to participate in an interview
- Willing and able to attend study visits
- Willing and able to return for 2-year-followup visit Exclusion Criteria for Study Partners
- Unwilling to answer questions about the participant with MCI
The study team makes the final eligibility decision.
Where it's taking place
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baltimore, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.