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New treatment option for Non-small Cell Lung Cancer
Official title Savolitinib Plus Docetaxel as 2L in EGFR/ALK/ROS1/MET ex14m-wildtype NSCLC With MET Overexpression
ClinicalTrials.gov ID: NCT05777278
What this study is testing
What is Savolitinib?
Savolitinib is an investigational medicine, being studied as a potential treatment for non-small cell lung cancer.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a prospective, pilot, single-arm, single-center study exploring the efficacy and safety of savolitinib plus docetaxel as second-line therapy in patients with MET overexpressed, EGFR/ALK/ROS1/MET ex14m-wildtype advanced NSCLC. Participants will receive treatment of docetaxel (60 mg/m2, ivgtt, q3w) in combination with savolitinib (300mg or 200mg according to safety run-in recommendation, p.o., BID) after informed consent signed.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF)...
- Provision of signed and dated, written ICF prior to any mandatory study specific procedures, sampling, and analyses.
- Female or males age ≥18 years at the time of signing the ICF.
- Histologically or cytologically confirmed locally advanced or metastatic EGFR/ALK/ROS1/MET ex14m-wildtype NSCLC.
- Has only received first line systemic treatment of non-targeted advanced NSCLC.
You likely can't join if
- As judged by the investigator, active gastrointestinal disease or other condition that will interfere significantly with the absorption...
- Any of the following cardiac diseases currently or within the last 6 months:
- Unstable angina pectoris
- Congestive heart failure (New York Heart Association [NYHA] ≥Grade 2)
- Acute myocardial infarction
- Stroke or transient ischemic attack
See the full eligibility criteria
Who can join
- Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.
- Provision of signed and dated, written ICF prior to any mandatory study specific procedures, sampling, and analyses.
- Female or males age ≥18 years at the time of signing the ICF.
- Histologically or cytologically confirmed locally advanced or metastatic EGFR/ALK/ROS1/MET ex14m-wildtype NSCLC.
- Has only received first line systemic treatment of non-targeted advanced NSCLC.
- Prior MET inhibitor therapy is not allowed.
- At least 28 days since last treatment.
- MET overexpression as determined IHC on tumor tissue.
- MET overexpression by IHC, 3+ in ≥50% of tumor cells
- Local IHC results are acceptable.
- WHO or Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 with no deterioration over the previous 2 weeks prior to baseline or day of first dosing and a minimum life expectancy of 12 weeks.
- At least 1 lesion that can be accurately measured at baseline as ≥10 mm in the longest diameter (except lymph nodes, which must have short axis ≥15 mm) with computed tomography (CT) or magnetic resonance imaging (MRI)...
- Adequate haematological function defined as:
- Haemoglobin ≥9 g/dL (no transfusion in the past 2 weeks).
- Absolute neutrophil count ≥1.5×10\^9/L.
- Platelet count ≥100,000/μL (no transfusion in the past 10 days)
- Adequate liver function defined as:
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 x the upper limit of normal (ULN) with total bilirubin (TBL) ≤ ULN
- OR TBL \>ULN to ≤1.5x ULN with ALT and AST ≤ ULN, alkaline phosphatase (ALP) ≤ 2.5x ULN
- Adequate renal function defined as a serum creatinine \ 1.5 times ULN.
- Adequate coagulation parameters, defined as: -International Normalisation Ratio (INR) \<1.5 and activated partial thromboplastin time \<1.5 x ULN unless patients are receiving therapeutic anti coagulation which affects...
- Patients with known tumor thrombus or deep vein thrombosis are eligible if clinically stable on low molecular weight heparin (LMWH) for ≥2 weeks.
- Ability to swallow and retain oral medications.
- Willingness and ability to comply with study and follow-up procedures.
- Females of childbearing potential should be willing to use highly effective contraceptive measures, should not be breast feeding, and must have a negative pregnancy test if of childbearing potential or must have...
- Male patients with a female partner of childbearing potential should be willing to use barrier contraception during the study and for 6 months following discontinuation of study drug. Patients should refrain from...
What rules you out
- As judged by the investigator, active gastrointestinal disease or other condition that will interfere significantly with the absorption, distribution, metabolism, or excretion of oral therapy (eg, ulcerative disease...
- Any of the following cardiac diseases currently or within the last 6 months:
- Unstable angina pectoris
- Congestive heart failure (New York Heart Association [NYHA] ≥Grade 2)
- Acute myocardial infarction
- Stroke or transient ischemic attack
- Uncontrolled hypertension (BP ≥150/95 mmHg despite medical therapy).
- Mean resting correct QT interval (QTcF) \>470 msec for women and \>450 msec for men on screening obtained from 3 electrocardiograms (ECGs) or factors that may increase the risk of QTcF prolongation such as chronic...
- Any clinically important abnormalities in rhythm, conduction or morphology of resting electrocardiograms (ECGs), e.g. complete left bundle branch block, third degree heart block, second degree heart block, PR interval...
- Serious underlying medical condition at the time of treatment that would impair the ability of the patient to receive protocol treatment.
- Wide field radiotherapy (including therapeutic radioisotopes such as strontium 89) administered ≤28 days or limited field radiation for palliation ≤7 days prior to starting study drug or has not recovered from side...
- Major surgical procedures ≤28 days of beginning study drug or minor surgical procedures ≤7 days. No waiting is required following port-a-cath placement.
- As judged by the investigator, any evidence of severe or uncontrolled systemic diseases, including renal transplant, active bleeding diatheses or uncontrolled hypertension, which in the investigator's opinion makes it...
- Active hepatitis B (HBV) (positive HBV surface antigen [HBsAg] result) or hepatitis C (HCV). Patients with a past or resolved HBV or HCV infection are eligible if:
- Negative for HBsAg and positive for hepatitis B core antibody [anti-HBc] or
- Positive for HBsAg, but for \>6 months have had normal transaminases and HBV DNA levels between 0 to 2000 IU/mL (inactive carrier state) and willing to start and maintain antiviral treatment for at least the duration of...
- Patients with a past or resolved HBV infection must have monthly monitoring of ALT and HBV DNA
- HBV DNA levels \>2000 IU/mL but on prophylactic antiviral treatment for the past 3 months and will maintain the antiviral treatment during the study.
- Patients with positive HCV antibody are eligible only if the polymerase chain reaction is negative for HCV ribonucleic acid.
- Presence of other active cancers, or history of treatment for invasive cancer, within the last 5 years. Patients with Stage I cancer who have received definitive local treatment at least 3 years previously and are...
- Unresolved toxicities from any prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 at the time of starting study treatment/randomization with the exception of alopecia.
- Spinal cord compression or brain metastases unless asymptomatic, stable, and not requiring steroids for at least 2 weeks prior to start of study intervention. people with leptomeningeal metastases are ineligible.
- Past medical history of ILD/pneumonitis, drug-induced ILD, radiation pneumonitis which required steroid treatment, or any evidence of clinically active ILD.
- Known serious active infection including, but not limited to, tuberculosis, or human immunodeficiency virus (positive human immunodeficiency virus 1/2 antibodies).
- History of liver cirrhosis of any origin and clinical stage; or history of other serious liver disease or chronic disease with relevant liver involvement, with or without normal LFTs, such as
- Hemochromatosis
- Alpha-1 Antitrypsin deficiency
- Autoimmune hepatitis (AIH)
- Primary sclerosing cholangitis (PSC)
- Primary biliary cirrhosis (PBC)
- Biopsy-confirmed Non-Alcoholic Steatohepatitis (NASH) with advanced fibrosis
- Biopsy- confirmed Alcoholic Steatohepatitis with advanced fibrosis
- Wilson's disease
- Hepatocellular carcinoma
- Known contraindications to docetaxel administration.
- Known hypersensitivity to the active or inactive excipients of docetaxel or savolitinib or drugs with a similar chemical structure or class.
- Women who are either pregnant or breast-feeding.
- Patients with previous medical history of Stevens Johnson syndrome (SJS) and serious cutaneous toxicity.
- Prior exposure to HGF/MET inhibitors, e.g., foretinib, crizotinib, cabozantinib, merestinib, onartuzumab, capmatinib, tepotinib, etc.
- Patients currently receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be strong inducers of CYP3A4, strong inhibitors of CYP1A2, within 2...
- Participation in another clinical study with a study treatment medication administered within five half-lives of the compound or 3 months, whichever is greater or investigational medicinal device administered in the...
- Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site).
- Judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions and requirements.
- For women only-Currently breastfeeding.
- Previous enrolments in the present study.
- Without civil capacity or with restricted civil capacity.
- Any other reasons judged by the leading investigator to prevent the subject from participating in this study.
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.