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New treatment option for Stroke
Official title Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation
ClinicalTrials.gov ID: NCT05766059
What this study is testing
- What it's testing
- Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called "mirror-PAS"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- for stroke patients:
- age from 18 to 85 years
- single, unilateral, hemispheric stroke (cortical or sub-cortical areas)
- stroke confirmed by neuroimaging (CT or MRI)
- stroke at least 4 months before enrollment
You likely can't join if
- for stroke patients:
- contraindications to TMS (Rossi et all, 2021)
- other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)
- other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome) Inclusion criteria for PLP patients:
- age from 18 to 90 years
- amputation of one part of the upper limb at least 2 months before enrollment
See the full eligibility criteria
- for stroke patients:
- age from 18 to 85 years
- single, unilateral, hemispheric stroke (cortical or sub-cortical areas)
- stroke confirmed by neuroimaging (CT or MRI)
- stroke at least 4 months before enrollment
- hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented
- for stroke patients:
- contraindications to TMS (Rossi et all, 2021)
- other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)
- other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome) Inclusion criteria for PLP patients:
- age from 18 to 90 years
- amputation of one part of the upper limb at least 2 months before enrollment
- presence of stable phantom limb pain at least 2 months prior to enrollment Exclusion criteria for PLP patients:
- contraindications to TMS (Rossi et all, 2021)
- other neurological, orthopedical or psychiatric conditions
The study team makes the final eligibility decision.
Where it's taking place
- Milan, Lombardy, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Milan, Lombardy, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.