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New treatment option for Monkeypox
Official title Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
ClinicalTrials.gov ID: NCT05745987
What this study is testing
What is Bavarian Nordic smallpox vaccine?
Bavarian Nordic smallpox vaccine is an investigational medicine, being studied as a potential treatment for monkeypox.
Also referred to as Imvamune.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 2 and older. Healthy volunteers may be eligible.
You may be able to join if
- Household member of person with laboratory confirmed mpox
- Age ≥ 2 years
- Within 14 days of onset of illness in mpox index case
You likely can't join if
- Pregnancy
- Breastfeeding
- Past serious allergic reaction to study vaccine components
- Previous smallpox vaccination
- Current or planned use of another investigational drug at any point during study participation
The study team makes the final eligibility decision.
Where it's taking place
- Kinshasa, Bukavu, Democratic Republic of the Congo
- Abuja, Nigeria
- Ibadan, Nigeria
- Irrua, Nigeria
- Kano, Nigeria
- Lagos, Nigeria
- Okolobiri, Nigeria
- Port Harcourt, Nigeria
- Kampala, Uganda
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 2 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kinshasa, Bukavu, Democratic Republic of the Congo; Abuja, Nigeria; Ibadan, Nigeria; Irrua, Nigeria; Kano, Nigeria; Lagos, Nigeria and 3 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.