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New treatment option for Voice Change
Official title The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia
ClinicalTrials.gov ID: NCT05732883
What this study is testing
What is Dexamethasone?
Dexamethasone is an investigational medicine, given as an injectable medicine, being studied as a potential treatment for voice change.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Aged 18 or above
- Patients undergoing total thyroidectomy for benign pathologies
- Toxic nodular goitre
- Graves' disease
You likely can't join if
- Non-communicable patients
- Patients contraindicated for steroid (DM, Hepatitis carrier, Tuberculosis, peptic ulcer disease)
- Patients contraindicated for analgesics including Panadol, Celebrex, Tramadol or Levobupivacaine
- Malignant thyroid disease
- Patients with previous thyroid surgery, or neck surgery
- Pre-existing hoarseness of voice of any cause or pre-existing vocal cord palsy
See the full eligibility criteria
- Aged 18 or above
- Patients undergoing total thyroidectomy for benign pathologies
- Toxic nodular goitre
- Graves' disease
- Non-communicable patients
- Patients contraindicated for steroid (DM, Hepatitis carrier, Tuberculosis, peptic ulcer disease)
- Patients contraindicated for analgesics including Panadol, Celebrex, Tramadol or Levobupivacaine
- Malignant thyroid disease
- Patients with previous thyroid surgery, or neck surgery
- Pre-existing hoarseness of voice of any cause or pre-existing vocal cord palsy
- Pregnancy / Lactating female patients
- Pre-existing renal disease / autoimmune disease on steroids
- Patients who require steroid cover during operation e.g. hydrocortisone perioperatively
The study team makes the final eligibility decision.
Where it's taking place
- Hong Kong, Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hong Kong, Hong Kong. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.